Fast and sensitive metronidazole determination by means of voltammetry on renewable amalgam silver based electrode without the preconcentration step

Robert Piech, Joanna Smajdor, Beata Paczosa-Bator, Martyna Rumin

Abstract


Application of cyclic renewable amalgam silver based electrode (Hg(Ag)FE) for sensitive metronidazole detection by differential pulse voltammetry (DPV) is described. The unique properties of the Hg(Ag)FE such as relative large surface area and its fast and very simple renewal were fully utilized for sensitive measurements. Compared with classical hanging mercury drop electrode (HMDE), renewable Hg(Ag)FE significantly increases the reduction peak current of metronidazole because of its large surface area. The effects of various factors for the metronidazole determination such as: pulse height and width, step potential, surface area of the working electrode, and basic electrolyte composition are optimized. The obtained calibration graph is linear from 0.1 µM (17 μg L-1) to 2 µM (342 μg L-1) with correlation coefficient 0.999. For the Hg(Ag)FE with the surface area of 10.1 mm2 the limit of detection (LOD) is 20 nM (3.4 μg L-1). The repeatability of the method at a concentration of the analyte 0.5 µM (5.6 μg L-1), expressed as relative standard deviation (RSD) is 2.1 % (n=7). The proposed method was successfully applied and confirmed by studying recovery of metronidazole from spiked samples.


Keywords


metronidazole; drugs; amalgam film electrodes; voltammetry

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References


J. C. Mucklow, Martindale: The Complete Drug Reference, Pharmaceutical Press, London, Great Britain, 2009

M. E. Mutschler, G. Geisslinger, H. K. Kroemer, P. Ruth, M. Schaefer-Korting, Farmakologia i toksykologia, MedPharm, Wrocław, Poland, 2010

L. L. Brunton, J. S. Lazo, K. L. Parker, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, New York, USA, 2005

P. Durel, V. Roiron, A. Siboulet, L. J. Borel, Brit. J. vener. Dis. 36 (1960) 21

C. D. Freeman, N. E. Klutman, K. C. Lamp, Drugs 54 (1997) 679

N. Van Eyk, J. van Schalkwyk, J. Obstet. Gynaecol. Canada 34 (2012) 382

M. O. Robbie, R. L. Sweet, Am. J. Obstet. Gynecol. 145 (1983) 865

J. D. Smilack, W. R. Wilson, F. R. Cockerill, Mayo. Clin. Proc. 66 (1991) 1270

World Health Organization, WHO Model list of essential medicines, 18th list (2013)

P. Thulasamma, P. Venkateswarlu, Rasayan J. Chem. 2 (2009) 865

M. R. El-Ghobashy, N. F. Abo-Talib, J. Adv. Res. 1 (2010) 323

K. Siddappa, M. Mallikarjun, P. T. Reddy, M. Tambe, Eclet. Quim. 33 (2008) 41

W. H. Ibrahim, W. A. Bashir, Raf. J. Sci. 23 (2012) 78

T. Saffaj, M. Charrouf, A. Abourriche, Y. Abboud, A. Bennamara, M. Berrada, Farmaco 59 (2004) 843

A. Menelaou, A. A. Somogyi, M. L. Barclay, F. Bochner, J. Chromatogr. B. Biomed. Sci. Appl. 731 (1999) 261

A. Marques, Cancer 146 (1978) 163

P. K. F. Yeung, R. Little, Y. Jiang, S. J. Buckley, P. T. Pollak, H. Kapoor, S. J. O. Veldhuyzen Van Zanten, J. Pharm. Biomed. Anal. 17 (1998) 1393

C. Ho, D. W. M. Sin, K. M. Wong, H. P. O. Tang, Anal. Chim. Acta 530 (2005) 23

N. W. Ali, M. Gamal, M. Abdelkawy, Pak. J. Pharm. Sci. 26 (1990) 865

E. Daeseleire, H. De Ruyck, R. Van Renterghem, Analyst 125 (2000) 1533

R. Lindberg, P. A. Jarnheimer, B. Olsen, M. Johansson, M. Tysklind, Chemosphere 57 (2004) 1479

W. Tian, L. Gao, Y. Zhao, W. Peng, Z. Chen, Anal. Methods 5 (2013)1283

M. A. La-Scalea, S. H. P. Serrano, I. G. R. Gutz, J. Braz. Chem. Soc. 10 (1999) 127

H. B. Ammar, M. Ben Brahim, R. Abdelhedi, Y. Samet, Mater. Sci. Eng. C 59 (2016) 604

H. B. Ammar, M. Ben Brahim, R. Abdelhédi, Y. Samet, Sep. Purif. Technol. 157 (2016) 9

B. Rezaei, S. Damiri, Electrochim. Acta 55 (2010) 1801

P. C. Mandal, J. Electroanal. Chem. 570 (2004) 55

R. Joseph, K. G. Kumar, Anal. Lett. 42 (2009) 2309

H. Zhai, Z. Liang, Z. Chen, H. Wang, Z. Liu, Z. Su, Q. Zhou, Electrochim. Acta 171 (2015) 105

S. Lu, K. Wu, X. Dang, S. Hu, Talanta 63 (2004) 653

A. Salimi, M. Izadi, R. Hallaj, M. Rashidi, Electroanalysis 19 (2007) 1668

I. Saidi, I. Soutrel, F. Fourcade, A. Amrane, N. Bellakhal, F. Geneste, Electrochim. Acta 191 (2016) 821

N. Xiao, J. Deng, J. Cheng, S. Ju, H. Zhao, J. Xie, D. Qian, J. He, Biosens. Bioelectron. 81 (2016) 54

H. Song, L. Zhang, F. Yu, B.-C. Ye, Y. Li, Electrochim. Acta 208 (2016) 10

S. A. Ozkan, Y. Ozkan, Z. Sentürk, J. Pharm. Biomed. Anal. 17 (1998) 299

Y. Gu, W. Liu, R. Chen, L. Zhang, Z. Zhang, Electroanalysis 25 (2013) 1209

B. Baś, Z. Kowalski, Electroanalysis 14 (2002) 1067

M. Grabarczyk, B. Baś, M. Korolczuk, Microchim. Acta 164 (2009) 465

R. Piech, B. Baś, W. W. Kubiak, B. Paczosa-Bator, Fuel 97 (2012) 876

R. Piech, Electroanalysis 21 (2009) 1842

M. Korolczuk, K. Tyszczuk, M. Grabarczyk, Electrochem. commun. 7 (2005) 1185

K. Tyszczuk, M. Korolczuk, M. Grabarczyk, Talanta 71 (2007) 2098

S. Smarzewska, S. Skrzypek, W. Ciesielski, Electroanalysis 24 (2012) 1591

S. Skrzypek, S. Smarzewska, W. Ciesielski, Electroanalysis 24 (2012) 1153

A. Bobrowski, A. Królicka, M. Putek, J. Zarȩbski, N. Čelebic, V. Guzsvány, Electrochim. Acta 107 (2013) 93–102

J. Smajdor, R. Piech, B. Paczosa-Bator, Electroanalysis 28 (2016) 394

J. Smajdor, R. Piech, M. Rumin, B. Paczosa-Bator, Z. Smajdor, J. Electrochem. Soc. 163 (2016) H605

J. Smajdor, R. Piech, M. Rumin, B. Paczosa-Bator, Electrochim. Acta 182 (2015) 67

R. Piech, B. Paczosa-Bator, Cent. Eur. J. Chem. 11 (2013) 736

J. Barek, J. Fischer, T. Navratil, K. Peckova, B. Yosypchuk, Sensors (Basel) 6 (2006) 445

I. Jiranek, K. Peckova, Z. Kralova, J. C. Moreira, J. Barek, Electrochim. Acta 54 (2009) 1939

B. Yosypchuk, J. Barek, Crit. Rev. Anal. Chem. 39 (2009)189

A. Danhel, J. Barek, Curr. Org. Chem. 15 (2011) 2957

A. Danhel, V. Mansfeldova, P. Janda, V. Vyskocil, J. Barek, Analyst 136 (2011) 3656

D. Deylova, B. Yosypchuk, V. Vyskocil, J. Barek, Electroanalysis 23 (2011) 1548

B. Yosypchuk, T. Navratil, A. N. Lukina, K. Peckova, J. Barek, Chem. Anal. (Warsaw, Pol.) 52 (2007) 897

V. Vyskocil, T. Navratil, A. Danhel, J. Dedik, Z. Krejcova, L. Skvorova, J. Tvrdikova, J. Barek, Electroanalysis 23 (2011) 129

P. Zuman, Z. Fijalek, J. Electroanal. Chem. 296 (1990) 583

A. El Jammal, J. C. Vire, G. J. Patriarche, O. Nieto Palmeiro, Electroanalysis 4 (1992) 57

Y. Gu, W. Liu, R. Chen, L. Zhang, Z. Zhang, Electroanalysis 25 (2013) 1209

A. Salimi, M. Izadi, R. Hallaj, M. Rashidic, Electroanalysis 19 (2007) 1668

G. O. El-Sayed, S. A. Yasin, A. A. El Badawy, Arab. J. Chem. 3 (2010) 167

A. M. O. Brett, S. H. P. Serrano, I. G. R. Gutz, M. A. La-Scalea, Electroanalysis 9 (1997) 1132

A. Hernandez-Jimenez, G. Roa-Morales, H. Reyes-Perez, P. Balderas-Hernandez, C. E. Barrera-Diaz, M. Bernabe-Pineda, Electroanalysis 28 (2016) 704




DOI: http://dx.doi.org/10.2298/JSC160529052P

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