Degradation of benzodiazepines using water falling film dielectric barrier discharge reactor

Vesna M. Radulović, Goran M. Roglić, Dragan D. Manojlović

Abstract


Classical methods of wastewater treatment are often not suitable for treatment of pharmaceutical waste. Previous studies have shown that the use of advanced oxidation procedures (AOP) can lead to a more efficient degradation of various biologically active compounds, which are active pharmaceutical ingredients of applied drugs. The aim of this paper is the application of plasma technology on degradation of a two active pharmaceutical ingredients (APIs) (diazepam and alprazolam) and finished products (Bensedin® and Ksalol®) using dielectric barrier discharge (DBD) reactor as advanced oxidation processes (AOP). We were studied degradation rate of these pharmaceuticals, depending on the number of passes through the reactor. Most effected by this degradation method were diazepam (61 %) and alprazolam (95%). We also examined influence of the pH adjustment between the passes of APIs through the DBD reactor. The degradation rate of APIs and finished products was monitored by high performance liquid chromatography (HPLC) technique, using a photodiode array detector. The concentration of dissolved ozone was determined using the iodometric procedure.


Keywords


alprazolam; diazepam; oxidation; pollutants

Full Text:

PDF (1,107 kB)

References


H. R. Buser, T. Poiger, M. D. Muller, Environ. Sci. Technol. 33 (1999) 2529

O. A. H. Jones, N. Voulvoulis, J. N. Lester, Environ. Technol. 22 (2001) 1383

U. Jux, R. M. Baginski, H. G. Arnold, M. Kronke, P. N. Seng Int. J. Hyg. Environ. Health 205 (2002) 393

D. W. Kolpin, E. T. Furlong, M. Meyer, E. M. Thurman, S. D. Zaugg, L. B. Barber, H. T. Buxton, Environ. Sci. Technol. 36 (2002) 1202

M. Stumpf, T.A. Ternes, R. D. Wilken, S. V. Rodrigues, W. Baumann, Sci. Total Environ. 225 (1999) 135

T. A. Ternes, Water Res. 32 (1998) 3245

C. Tixier, H. P. Singer, S. Oellers, S. R. Muller, Environ. Sci. Technol. 37 (2003) 1061

T. Ternes, M. Bonerz, T. Schmidt, J. Chromatogr. A 938 (1-2) (2001) 175

M. J. Martínez Bueno, M. D. Hernando, S. Herrera, M. J. Gómez, A. R. Fernández-Alba, I. Bustamante, E. García-Calvo, Int. J. Environ. An. Ch. 90 (2010) 321

E. Zuccato, D. Calamari, M. Natangelo, R. Fanelli, The Lancet 355 (2000) 1789

F. Stuer-Lauridsen, M. Birkved, L. P. Hansen, H. C. Holten Lutzhoft, B. Harling-Sorensen, Chemosphere 40 (2000) 783

C. H. Redswhaw, M. P. Cooke, H. M. Talbot, S. McGrath, S. J. Rowlan, J. Soils Sediments 8 (2008) 217

M. J. Martínez Bueno, A., Agüera, M. J. Gómez, M. D. Hernando, J. F. García-Reyes, A. R. Fernández-Alba, Anal. Chem. 79 (2007) 9372

T. Heberer, J. Hydrol. 266 (3, 4) (2002) 175

D. R. Baker, B. Kasprzyk-Hordern, J. Chromatogr. A 1218 (2011) 1620

J. B. Belden, J. D. Maul, M. J. Lydy, Chemosphere 66 (2007) 1390

V. Calisto, V.I. Esteves, Chemosphere 77 (10) (2009) 1257

Y. Liu, S. Mei, D. Iya-Sou, S. Cavadias, S. Ognie, Chem. Eng. Process. 56 (2012) 10

M. Magureanu, D. Piroi, N. B. Mandache, V. David, A. Medvedovici, V. I. Parvulescu, Water Res. 44 (2010) 3445.

M. Magureanu, D. Piroi, N. B. Mandache, V. David, A. Medvedovici, C. Bradu, V. I. Parvulescu, Water Res. 45 (2011) 3407

N. Lu, J. Li, X. Wang, T. Wang, Y. Wu, Plasma Chem Plasma P. 32 (2012) 109

K. Ikehata, N. J. Naghashkar, M. G. El-Din, Sci. Eng. 28 (2006) 353

Y. Liua, S. Mei, D. Iya-Sou, S. Cavadias, S. Ognier, Chem. Eng. Process. 56 (2012) 10

M. M. Kuraica, B. M. Obradović, D. Manojlović, D. R. Ostojić, J. Purić, Vacuum 73 (2004) 705

D. Manojlovic, D. R. Ostojic, B. M. Obradovic, M. M. Kuraica, V. D. Krsmanovic, J. Puric, Desalination 213 (2007) 116

B. P. Dojčinović, D. Manojlović, G. M. Roglić, B. M. Obradović, M. M. Kuraica, J. Purić, Vacuum 83 (2009) 234

B. P. Dojčinović, G. M. Roglić, B. M. Obradović, M. M. Kuraica, M. M. Kostić, J. Nešić, D. D. Manojlović, J. Hazard. Mater. 192 (2011) 763

B. M. Obradović, G. B. Sretenović, M. M. Kostić, M. M. Kuraica, J. Hazard. Mater. 185 (2011) 1280

M. Jović, D. Manojlović, D. Stanković, B. Dojčinović, B. Obradović, U. Gašić, G. Roglić, J. Hazard. Mater. 260 (2013) 1092

S. M. Jović, B. P. Dojčinović, V. V. Kovačević, B. M. Obradović, M. M. Kuraica, U. M. Gašić, G. M. Roglić, Chem. Eng. J. 248 (2014) 63

M. Marković, M. Jović, D. Stanković, V. Kovačević, G. Roglić, G. Gojgić-Cvijović, D. Manojlović Sci. Total Environ. 505 (2015) 1148

B. P. Dojčinović, B. M. Obradović, M. M. Kuraica, M. V. Pergal, S. D. Dolić, D. R. Inđić, T. B. Tosti, D. D. Manojlović J. Serb. Chem. Soc. 81 (7) (2016) 829

M. M. Aonyas, B. P. Dojčinović, S. D. Dolić, B. M. Obradović, D. D. Manojlović, M. D. Marković, G. M. Roglić J. Serb. Chem. Soc. 81 (9) (2016) 1097

C.G. Cabrera, R. Goldberg De Waisbaum, N. S. Nudelman, J. Phys. Org. Chem. 18 (2005) 156

N. S. Nudelman, C. Gallardo Cabrera, J. Pharm. Sci. 91 (5) (2002) 1274

C. E. West, S. J. Rowland, Environ. Sci. Technol. 46 (2012) 4749

Y. Chen, C. Hu, J. Qu, M. Yang, J. Photoch. Photobio. A 197 (1) (2008) 81




DOI: http://dx.doi.org/10.2298/JSC170118050R

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 J. Serb. Chem. Soc.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

IMPACT FACTOR 0.822 (131 of 166 journals)
5 Year Impact Factor 1.015 (118 of 166 journals)