Highly invasive alien plant Reynoutria japonica Houtt. represents a novel source for pharmaceutical industry – evidence from phenolic profile and biological activity

Biljana Božin, Marjana Gavrilović, Nebojša Kladar, Milica Rat, Goran Anačkov, Neda Gavarić

Abstract


Reynoutria japonica is on the IUCN list of the Worlds’100 worst invasive species, but it is also, especially its rhizome, an integral part of Traditional Chinese Medicine. The objective of this study was to determine the amount of selected phenolic compounds in rhizome, stems, leaves and inflorescence methanol extracts of this plant, their antioxidant and anticholinesterase activity. The chemical profile of the examined extracts was obtained by a high-performance liquid chromatography. In vitro assays on DPPH, OH and NO radicals were used to estimate antioxidant potential and Ellman’s method was applied for the determination of anticholinesterase activity. Leaves and rhizome extracts were found to be rich in rosmarinic and chlorogenic acid, and selected flavonoids. Resveratrol was exclusively present in rhizome and stems extracts. All the investigated extracts expressed certain antioxidant activity, where leaves extract was the most active. However, rhizome extract was the strongest inhibitor of acetylcholinesterase. These findings indicate that there is a possibility of R. japonica exploitation for the isolation of biologically active phenolic compounds used in pharmaceutical and food industry.


Keywords


Polygonum cuspidatum; trans-resveratrol; antioxidant effect; anticholinesterase activity; phenolic acids; flavonoids

Full Text:

PDF (1,176 kB)

References


P. Stypinski, Fragm. Florist. Geobot. 23 (1997) 316

P. Pyšek, K. Prach, In Ecosystem Management; Springer: 1993, 254

I. Trinajstić, J. Franjić, D. Kajba, Acta Bot. Croat. 53 (1994) 145

B. Mandak, P. Pysek, K. Bimova, Preslia 76 (2004) 15

S. Lowe, M. Browne, S. Boudjelas, M. De Poorter, 100 of the world's worst invasive alien species: a selection from the global invasive species database; ISSG, 2000

A. W. Sheppard, R. H. Shaw, R. Sforza, Weed Res. 46 (2006) 93

M. Glavendekić, Šumarstvo 60 (2008) 67

W. Peng, R. Qin, X. Li, H. Zhou, J. Ethnopharmacol. 148 (2013) 729

K. W. Kim, K. T. Ha, C. S. Park, U. H. Jin, H. W. Chang, I. S. Lee, C. H. Kim, Vascul. Pharmacol. 47 (2007) 99

J. Burns, T. Yokota, H. Ashihara, M. E. Lean, A. Crozier, J. Agric. Food Chem. 50 (2002) 3337

W. Chun-Fu, Y. Jing-Yu, W. Fang, W. Xiao-Xiao, Chin. J. Nat. Med. 11 (2013) 1

F. Li, Z. Zhan, F. Liu, Y. Yang, L. Li, Z. Feng, J. Jiang, P. Zhang, Org. Lett. 15 (2013) 674

A. Y. Sun, A. Simonyi, G. Y. Sun, Free Radical Biol. Med. 32 (2002) 314

N. S. Lakic, N. M. Mimica-Dukic, J. M. Isak, B. N. Bozin, Cent. Eur. J. Biol. 5 (2010) 331

A. Ziaková, E. Brandšteterová, J. Liq. Chromatogr. Rel. Technol. 26 (2003) 443

R. Pezet, V. Pont, P. Cuenat, J. Chromatogr. 663 (1994) 191

B. Bozin, N. Mimica-Dukic, N. Simin, G. Anackov, J. Agric. Food Chem. 54 (2006) 1822

B. Bozin, N. Kladar, N. Grujic, G. Anackov, I. Samojlik, N. Gavaric, B. S. Conic, Molecules 18 (2013) 11733

G. L. Ellman, K. D. Courtney, V. Andres, Jr., R. M. Feather-Stone, Biochem. Pharmacol. 7 (1961) 88

N. Kladar, B. Srđenović, N. Grujić, B. Bokić, M. Rat, G. Anačkov, B. Božin, Braz. J. Bot. 38 (2015) 703

H. W. Lin, M. X. Sun, Y. H. Wang, L. M. Yang, Y. R. Yang, N. Huang, L. J. Xuan, Y. M. Xu, D. L. Bai, Y. T. Zheng, K. Xiao, Planta Med. 76 (2010) 889

Y. W. Lin, F. J. Yang, C. L. Chen, W. T. Lee, R. S. Chen, J. Nat. Med. 64 (2010) 146

V. Marques, A. Farah, Food Chem. 113 (2009) 1370

A. Farah, C. M. Donangelo, Braz. J. Plant Phys. 18 (2006) 23

H. J. Lee, H. S. Cho, E. Park, S. Kim, S. Y. Lee, C. S. Kim, D. K. Kim, S. J. Kim, H. S. Chun, Toxicology 250 (2008) 109

Z. Kuznetsova, Vestsi Akademii Navuk Belarusi, Seryya Biyalagichnykh Navuk 5 (1979) 29

S. Kumar, A. K. Pandey, Sci. World J. (2013) 162750

H. Temsamani, S. Krisa, J.-M. Mérillon, T. Richard, J. Nutr. Health Aging 3 (2015) 49

L. Bavaresco, C. Fregoni, E. Cantu, M. Trevisan, Drugs Exp. Clin. Res. 25 (1998) 57

N. Vrchotova, B. Sera, J. Triska, Acta Chromatogr. 19 (2007) 21

J. E. Klaunig, L. M. Kamendulis, Annu. Rev. Pharmacol. Toxicol. 44 (2004) 239

J. Shan-Hua, J. Guang-Shi, Z. Xing-Shan, Chin. J. Med. 9 (2009) 453

D. Jin-liang, J. Rui, C. Li-ping, Y. Guo-jun, Jiangxi Nongye Daxue Xuebao 5 (2012) 27

A. Gella, N. Durany, Cell Adh Migr 3 (2009) 88

M. B. Colovic, D. Z. Krstic, T. D. Lazarevic-Pasti, A. M. Bondzic, V. M. Vasic, Curr. Neuropharmacol. 11 (2013) 315.

V. Marques, A. Farah, Food Chem. 113 (2009) 1370

A. Farah, C. M. Donangelo, Braz. J. Plant Phys. 18 (2006) 23

H. J. Lee, H. S. Cho, E. Park, S. Kim, S. Y. Lee, C. S. Kim, D. K. Kim, S. J. Kim, H. S. Chun, Toxicology 250 (2008) 109

Z. Kuznetsova, Vestsi Akademii Navuk Belarusi, Seryya Biyalagichnykh Navuk 5 (1979) 29

S. Kumar, A. K. Pandey, Sci. World J. 2013 (2013) 162750

H. Temsamani, S. Krisa, J.-M. Mérillon, T. Richard, J. Nutr. Health Aging 3 (2015) 49

L. Bavaresco, C. Fregoni, E. Cantu, M. Trevisan, Drugs Exp. Clin. Res. 25 (1998) 57

N. Vrchotova, B. Sera, J. Triska, Acta Chromatogr. 19 (2007) 21

J. E. Klaunig, L. M. Kamendulis, Annu. Rev. Pharmacol. Toxicol. 44 (2004) 239

J. ShanHua, J. GuangShi, Z. XingShan, Chin. J. Med. 9 (2009) 453

D. Jin-liang, J. Rui, C. Li-ping, Y. Guo-jun, Jiangxi Nongye Daxue Xuebao 5 (2012) 27

A. Gella, N. Durany, Cell Adh Migr 3 (2009) 88

M. B. Colovic, D. Z. Krstic, T. D. Lazarevic-Pasti, A. M. Bondzic, V. M. Vasic, Curr. Neuropharmacol. 11 (2013) 315




DOI: http://dx.doi.org/10.2298/JSC170306054G

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 J. Serb. Chem. Soc.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

IMPACT FACTOR 0.822 (131 of 166 journals)
5 Year Impact Factor 1.015 (118 of 166 journals)