Microwave assisted synthesis of 1H-tetrazole based flavonoid derivatives and their antimicrobial activity

Main Article Content

Dongamanti Ashok
Nalaparaju Nagaraju
Madderla Sarasija
B Vijaya Lakshmi

Abstract

A series of novel tetrazole scaffolds containing chalcones 4a-e and aurones 5a-e have been synthesized under conventional and microwave irradiation methods. All the newly synthesized compounds were characterized by IR, NMR and Mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli as well as fungi such as Aspergillus Niger, Aspergillus flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all pathogenic bacteria and fungi.

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How to Cite
[1]
D. Ashok, N. Nagaraju, M. Sarasija, and B. Vijaya Lakshmi, “Microwave assisted synthesis of 1H-tetrazole based flavonoid derivatives and their antimicrobial activity”, J. Serb. Chem. Soc., vol. 83, no. 12, pp. 1305–1313, Dec. 2018.
Section
Organic Chemistry
Author Biographies

Dongamanti Ashok, DeparGreen and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania Universit, Hyderabad, 500007, Telangana

Professor in Chemistry

Dept. of Chemistry

Osmania University

Nalaparaju Nagaraju, DeparGreen and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania Universit, Hyderabad, 500007, Telangana

Green and Medicinal Chemistry Laboratory,

Department of Chemistry,

Osmania University, Hyderabad, 500007

 

Madderla Sarasija, Department of Chemistry, Satavahana University, Karimnagar, 505001, Telangana

Department of Chemistry,

Satavahana University,

Karimnagar, Telangana 505001.

B Vijaya Lakshmi, DeparGreen and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania Universit, Hyderabad, 500007, Telangana

Green and Medicinal Chemistry Laboratory,

Department of Chemistry,

Osmania University, Hyderabad, 500007

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