Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine

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Mădălina Mihalache
Ticuţa Negreanu-Pirjol
Florea Dumitraşcu
Constantin Drăghici
Mirela Călinescu

Abstract

: Six new coordination compounds of Ni(II), Pd(II) and Cr(III) with chlor­hexidine, 1,1′-hexamethylenebis[5-(4-chlorophenyl)biguanide], were pre­pared, characterized and examined for their potential as antimicrobial agents, as well as for their antioxidant activity. The metal complexes correspond to the formulas: [Ni(CHX)]Cl2·2H2O, [Ni(CHX)]Br2·2H2O, [Ni(CHX)](CH3COO)2·C2H5OH, [Pd(CHX)][PdCl4]·2H2O, [Pd(CHX)](CH3COO)2 and [Cr(CHX)Cl2](CH3COO), where CHX = chlorhexidine. Investigations on the in vitro antimicrobial act­ivity of the complexes indicated that all have high activity against the tested bacteria, but are less active against fungi. Among the six complexes, those of Pd(II) showed the highest antibacterial activity, [Pd(CHX)][PdCl4]·2H2O being more active against Gram-positive and Gram-negative bacteria than chlorhex­idine diacetate. The antioxidant activity of the metal complexes was inves­t­igated by photochemiluminescence and the results showed that the palla­dium(II) complexes have high antioxidant activities.

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How to Cite
[1]
M. Mihalache, T. Negreanu-Pirjol, F. Dumitraşcu, C. Drăghici, and M. Călinescu, “Synthesis, characterization and biological activity of new Ni(II), Pd(II) and Cr(III) complex compounds with chlorhexidine”, J. Serb. Chem. Soc., vol. 83, no. 3, pp. 271–284, Apr. 2018.
Section
Inorganic Chemistry
Author Biographies

Mădălina Mihalache, Faculty of Chemistry, University of Bucharest, Dumbrava Roşie 23, Bucharest 020462

Inorganic Chemistry Department, Chemist

Ticuţa Negreanu-Pirjol, Faculty of Pharmacy, Ovidius University, Aleea Universităţii 1, Constanţa 900470

Chemistry Department, Professor

Florea Dumitraşcu, Center of Organic Chemistry "C.D. Nenitzescu", Romanian Academy, 202B Spl. Independenţei, Bucharest 060023

Organic Chemistry Laboratory, Researcher

Constantin Drăghici, Center of Organic Chemistry "C.D. Nenitzescu", Romanian Academy, 202B Spl. Independenţei, Bucharest 060023

Organic Chemistry Laboratory, Researcher

Mirela Călinescu, Faculty of Chemistry, University of Bucharest, Dumbrava Roşie 23, Bucharest 020462

Inorganic Chemistry Department, Associate Professor

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