Furofuran lignans of Artemisia genus: Isolation, biosynthesis and biological activity


  • Jovana D. Ickovski Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš
  • Jovana Lj. Pavlović Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš
  • Milan N. Mitić Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš
  • Ivan R. Palić Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš
  • Danijela A. Kostić Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš
  • Goran M. Petrović Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš
  • Gordana S. Stojanović Department of Chemistry, Faculty of Science and Mathematics, Višegradska 33, 18000 Niš




artemisia, lignan, sesamin, sesartemin, diayangambin, epiyangambin


Since ancient times, medicinal plants and pharmacologically active products obtained from different natural sources play an important role in human health. Plants belonging to the genus Artemisia possess a great bio­logical potential and it is a well-studied genus in the fields such as systematics (including molecular phylogenetics) and genome organization. Many species of the genus (e.g., A. absinthium, A. annua, A. vulgaris, A. abro­tanum, A. arbo­res­cens) are widely exploited, because of their high economic value as medi­cines, food and ornamentals. Withal, in such a large genus, some hiatus must inevitably exist, concerning attainments and potentials that individual species possess. Most of the studies are focused on bioactivity and pharmacology of sesquiterpene lactones. Lignans are unjustly neglected, even though they as well exhibit a wide range of bioactivities. Motivated by that fact, we tried to consolidate findings on bioactive lignans accumulated through the years, with the logical perspectives on further work on isolation and identification of new bioactive lignans and the exploitation of lignans as substances of  potential pharmacological interest.


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How to Cite

J. D. Ickovski, “Furofuran lignans of Artemisia genus: Isolation, biosynthesis and biological activity”, J. Serb. Chem. Soc., vol. 85, no. 5, pp. 575-600, May 2020.