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/Author (Abniki, Milad and Moghimi, Ali and Azizinejad, Fariborz)
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/Title ({Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release})
/Keywords (anti-inflammatory drug,controlled release,hybrid material,intercalation compounds,layered double hydroxide)
/bibtex#2Fyear (2020)
/bibtex#2Fnumber (09)
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/bibtex#2Fpages (1223--1235)
/Subject (The study proposed a new formulation to the sustained delivery of mefenamate anions intercalated into Mg-Al layered double hydroxide \(LDH\) for oral administration. Different experimental conditions were evaluated to incorporate the mefenamic acid \(MEF\) and gum arabic \(GUM\) into LDH structure. The LDH-MEF and LDH-MEF/GUM were covered with chitosan \(CHIT\). In another experiment, LDH-Cl was used to adsorb mefenamate anions and evaluate the mechanism. The products of LDH were characterized by using different techniques such as FESEM \(field emission scanning electron microscopy\), XRD \(X-ray diffraction\), FTIR \(Fourier transform infrared\) spec-troscopy and TGA \(thermogravimetric analysis\). The X-ray diffraction patterns and FTIR analyses confirmed that the MEF and GUM were successfully inter-calated into the interlayer space of LDH. TG analysis verified that the thermal stability of intercalated MEF in the form of bionanocomposite \(LDH-MEF/ /GUM/CHIT\) was enhanced. Finally, In vitro drug release experiments of bio-nanocomposite at a pH of 1.2 \(acidic medium\) and a pH of 7.4 \(phosphate buffer medium\) showed sustained release profiles with mefenamate anions as an anti-inflammatory model drug.)
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anti-inflammatory drug
controlled release
hybrid material
intercalation compounds
layered double hydroxide
2020-09
{Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release}
bibtex/number/09
bibtex/file/:C\:/Users/Dekanski/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Abniki, Moghimi, Azizinejad - 2020 - Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating fo.pdf:pdf;:09_8696_5370.pdf:PDF
bibtex/journal/Journal of the Serbian Chemical Society
bibtex/pages/1223--1235
bibtex/url/https://www.shd-pub.org.rs/index.php/JSCS/article/view/8696
bibtex/volume/85
bibtex/issn/0352-5139
bibtex/month/sep
bibtex/bibtexkey/Abniki2020
Milad Abniki
Ali Moghimi
Fariborz Azizinejad
The study proposed a new formulation to the sustained delivery of mefenamate anions intercalated into Mg-Al layered double hydroxide (LDH) for oral administration. Different experimental conditions were evaluated to incorporate the mefenamic acid (MEF) and gum arabic (GUM) into LDH structure. The LDH-MEF and LDH-MEF/GUM were covered with chitosan (CHIT). In another experiment, LDH-Cl was used to adsorb mefenamate anions and evaluate the mechanism. The products of LDH were characterized by using different techniques such as FESEM (field emission scanning electron microscopy), XRD (X-ray diffraction), FTIR (Fourier transform infrared) spec-troscopy and TGA (thermogravimetric analysis). The X-ray diffraction patterns and FTIR analyses confirmed that the MEF and GUM were successfully inter-calated into the interlayer space of LDH. TG analysis verified that the thermal stability of intercalated MEF in the form of bionanocomposite (LDH-MEF/ /GUM/CHIT) was enhanced. Finally, In vitro drug release experiments of bio-nanocomposite at a pH of 1.2 (acidic medium) and a pH of 7.4 (phosphate buffer medium) showed sustained release profiles with mefenamate anions as an anti-inflammatory model drug.
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