Application of LC–MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential Scientific paper

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Published: Dec 21, 2021
Updated: 21.12.2021
DOI: https://doi.org/10.2298/JSC210812086S
Keywords:
tandem mass spectrometry parallel accumulation serial fragmentation ion mobility mass spectrometer poplar propolis quorum sensing P. aeruginosa

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Ivana Sofrenić
University of Belgrade – Faculty of Chemistry, Studentski trg 12–16, 11000 Belgrade, Serbia
https://orcid.org/0000-0002-9799-670X
Jovana Ljujić
University of Belgrade – Faculty of Chemistry, Studentski trg 12–16, 11000 Belgrade, Serbia,
https://orcid.org/0000-0002-0215-0155
Katarina Simić
University of Belgrade – Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia
https://orcid.org/0000-0001-5060-8936
Stefan Ivanović
University of Belgrade – Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia
https://orcid.org/0000-0002-3291-9818
Jovana Stanković Jeremić
University of Belgrade – Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia
Ana Ćirić
University of Belgrade – Institute for Biological Research “Siniša Stanković”, Bulevar despota Stefana 142, 11060 Belgrade, Serbia
https://orcid.org/0000-0002-9478-5448
Marina Soković
University of Belgrade – Institute for Biological Research “Siniša Stanković”, Bulevar despota Stefana 142, 11060 Belgrade, Serbia
https://orcid.org/0000-0002-7381-756X
Boban Anđelković
Faculty of Chemistry, Departmet of Organic Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrad, Serbia
https://orcid.org/0000-0002-9522-1492

Abstract

The objective of this study was to test four-dimensional LC-ESI-MS/MS chromatography in analysis of complex mixture such as ethanol extracts of different propolis samples. In total more than 1200 picks were identified and only for 185 literature conformation was found. The given data represent the result of tentative identification, and summarized results are given in the text. Comparing the samples, from different altitudes, 96 components were detected as characteristic in high altitude samples and 18 in samples collected at low altitudes. Antimicrobial activity of ethanol extracts of propolis (EEP) and pro­pyl­ene glycol extracts of propolis (PGEP) were carried out on S. aureus, B. cereus, M. flavus, L. monocytogenes, P. aeruginosa, S. typhimurium, E. coli and E. cloacae bacterial strains and compared with broad-spectrum antibiotics, streptomycin and ampicillin. Anti-quorum sensing activity was performed on P. aeruginosa by testing the effect of representative propolis extracts on bio­film formation, twitching and motility activity and production of pyocyanin. We demonstrated that the majority of explored propolis extracts have greater or equal minimal inhibitory concentration and minimum bactericidal concen­tra­tion values compared to antibiotics, independently of the solvent used for the extraction. The samples collected from the highest altitude emerged as least active antimicrobial agents but with the greatest potential as anti-quorum sen­sing agents.

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How to Cite
[1]
I. Sofrenić, “Application of LC–MS/MS with ion mobility for chemical analysis of propolis extracts with antimicrobial potential: Scientific paper”, J. Serb. Chem. Soc., vol. 86, no. 12, pp. 1205–1218, Dec. 2021.
Issue
Vol. 86 No. 12 (2021): Theme issue honoring Professor Emeritus Slobodan Milosavljevićs 80th birthday
Section
Theme issue honoring Professor Emeritus Slobodan Milosavljević's 80th birthday
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