Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines
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Abstract
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine has the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship.
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How to Cite
[1]
J. Penjisevic, “Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines”, J. Serb. Chem. Soc., vol. 81, no. 4, pp. 347–356, May 2016.
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Organic Chemistry
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