Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine

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Published: Apr 30, 2018
DOI: https://doi.org/10.2298/JSC161203070I
Keywords:
organotin(IV) complexes, spectroscopy, antioxidant, antimicrobial, DNA binding

Main Article Content

Syed Hassan Iftikhar
Department of Chemistry, University of Engineering and Technology, Lahore-54890
Syeda Rubina Gilani
Department of Chemistry, University of Engineering and Technology, Lahore-54890
M. Babar Taj
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320
Ahmad Raheel
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320
Imtiaz ud Din
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320
Syed Ahmad Tirmizi
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320
Mundher Al-Shakban
School of Chemistry, University of Manchester, M13 9PL, United Kingdom
Hapipah Mohd Alie
Department of Chemistry, University of Malaya, Malaysia, Kuala Lumpur 50603

Abstract

Six new organotin(IV) derivatives [Me3SnL1] (1), [Bu3SnL1] (2), [Ph3SnL1] (3), [Me3SnL2] (4), [Bu3SnL2] (5) and [Ph3SnL2] (6) (where HL1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-car­bo­xylic acid (flumequine) and HL2 = 2-[2-[4-[(4-chlorophenyl)phenyl­methyl]-
-1-piperazinyl]ethoxy] acetic acid (cetirizine)) were synthesized and charac­ter­ized by elemental analysis, FT-IR spectroscopy, multinuclear 1H-, 13C- and 119Sn-NMR, mass spectrometry and thermal analysis techniques. The obtained data reveal trigonal-bipyramidal geometry in case of complexes 1, 2, 4 and 5, and tetrahedral geometry for complexes 3 and 6 around the tin atom, whereas in complexes 3 and 6 the carboxylate ligand act as monodentate ligand through one of its oxygen atoms while it acts as bidentate ligand through two oxygen atoms for complexes 1, 2, 4 and 5. The antibacterial and antifungal efficacies of complexes 1–6 were assessed and the majority of the compounds showed good activities. The present research showed that the trimethyltin(IV) derivat­ives were particularly more effective than tributyltin(IV) and triphenyltin(IV) derivatives against all the bacterial and fungal strains. Antioxidant and DNA binding studies were also performed and promising results were obtained.

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How to Cite
[1]
S. H. Iftikhar, “Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine”, J. Serb. Chem. Soc., vol. 83, no. 4, pp. 425–437, Apr. 2018.
Issue
Vol. 83 No. 4 (2018)
Section
Inorganic Chemistry

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Author Biographies

Syed Hassan Iftikhar, Department of Chemistry, University of Engineering and Technology, Lahore-54890

Research Student,

Department of Chemistry, University of Engineering and Technology, Lahore.

Syeda Rubina Gilani, Department of Chemistry, University of Engineering and Technology, Lahore-54890

Professor,

Department of Chemistry, University of Engineering and Technology, Lahore.

M. Babar Taj, Department of Chemistry, Quaid-i-Azam University, Islamabad 45320

Researcher,

Department of Chemistry, Quaid-i-Azam University, Islamabad.

Ahmad Raheel, Department of Chemistry, Quaid-i-Azam University, Islamabad 45320

Researcher,

Department of Chemistry, Quaid-i-Azam University, Islamabad.

Imtiaz ud Din, Department of Chemistry, Quaid-i-Azam University, Islamabad 45320

Professor,

Department of Chemistry, Quaid-i-Azam University, Islamabad.

Syed Ahmad Tirmizi, Department of Chemistry, Quaid-i-Azam University, Islamabad 45320

Professor,

Department of Chemistry, Quaid-i-Azam University, Islamabad.

Mundher Al-Shakban, School of Chemistry, University of Manchester, M13 9PL, United Kingdom

Research-fellow,

Department of Chemistry, University of Manchester.

Hapipah Mohd Alie, Department of Chemistry, University of Malaya, Malaysia, Kuala Lumpur 50603

Professor,

Department of Chemistry, University of Malaya, Malaysia, Kuala Lumpur

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