Antibacterial and antifungal properties of guanylhydrazones

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Published: Aug 1, 2017
DOI: https://doi.org/10.2298/JSC170213033A
Keywords:
guanylhydrazones iminoguanidines antibacterial activity antifungal activity Candida spp

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Vladimir Ajdačić
Faculty of Chemistry, University of Belgrade, Studentski trg 16, P. O. Box 51, 11158, Belgrade
Jelena Lazić
Faculty of Chemistry, University of Belgrade, Studentski trg 16, P. O. Box 51, 11158, Belgrade
Marija Mojičević
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11000 Belgrade
Sandra Šegan
Institute of Chemistry, Technology, and Metallurgy, University of Belgrade, Njegoševa 12, 11000 Belgrade
Jasmina Nikodinović-Runić
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11000 Belgrade
Igor Opsenica
Faculty of Chemistry, University of Belgrade, Studentski trg 16, P. O. Box 51, 11158, Belgrade

Abstract

A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 µg/mL, and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that selected guanylhydrazones could serve as promising leads for the improved antimicrobial development.

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How to Cite
[1]
V. Ajdačić, J. Lazić, M. Mojičević, S. Šegan, J. Nikodinović-Runić, and I. Opsenica, “Antibacterial and antifungal properties of guanylhydrazones”, J. Serb. Chem. Soc., vol. 82, no. 6, pp. 641–649, Aug. 2017.
Issue
Vol. 82 No. 6 (2017)
Section
Organic Chemistry

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