Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine: A green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/tiones derivatives under solvent-free conditions

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Published: Jul 2, 2018
DOI: https://doi.org/10.2298/JSC170712041M
Keywords:
caffeine natural and green biodegradable catalyst Biginelli react¬ion 3 4-dihydropyrimidin-2(1H)-ones/tihones derivatives eco-safe procedure solvent-free conditions

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Farzaneh Mohamadpour
Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz
Mojtaba Lashkari
Faculty of Science, Velayat University, Iranshahr

Abstract

Caffeine was found to be a natural and green and biodegradable cat­alyst for the one-pot, three-component condensation Biginelli reaction of β-keto esters, aromatic aldehydes and urea/thiourea to afford the corres­pond­ing 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free conditions. The remarkable features of this green procedure are high yields, short reaction times, simplicity of operation and work-up procedures, the avail­ability and easy handling of this solid catalyst, avoidance of hazardous or toxic catalysts and organic solvents and economic availability of the catalyst.

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[1]
F. Mohamadpour and M. Lashkari, “Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine: A green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/tiones derivatives under solvent-free conditions”, J. Serb. Chem. Soc., vol. 83, no. 6, pp. 673–684, Jul. 2018.
Issue
Vol. 83 No. 6 (2018)
Section
Organic Chemistry

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