Binuclear copper(II) complexes: Synthesis, structural characterization, DNA binding and in silico studies

Main Article Content

Abdul Waheed Kamran
Saqib Ali
Muhammad Nawaz Tahir
Muhammad Zahoor
Abdul Wadood
Muhammad Iqbal
http://orcid.org/0000-0002-1716-7128

Abstract

Two new binuclear Cu(II) complexes represented by the general for­mula {(dmso)Cu(µ-L)4Cu(dmso)} (1) and {(Phen)(L)Cu(µ-L)2Cu(L)(Phen)} (2) where dmso = dimethyl sulphoxide, L = 2-bromophenyl acetate and Phen = 1,10-phenanthroline have been synthesized, isolated quantitatively and char­acterized by UV/Vis and FT-IR spectroscopic techniques, thermo­gra­vi­metry/differential thermal analysis and X-ray single crystal XRD studies. Complex 1 is paddlewheel with 1,2-O,O-bridging while 2 has 1,1-O-bridging. The values of the intrinsic binding constants with DNA were found out to be 2.0×103 and 1.1×103 M-1, respectively for compound 1 and 2. The mode of interaction of complexes with DNA was also evaluated through computational study by molecular docking (in silico) study using molecular operating environment (MOE) software. The synthesized complexes are structurally as well as bio­logically important.

Article Details

How to Cite
[1]
A. W. Kamran, S. Ali, M. N. Tahir, M. Zahoor, A. Wadood, and M. Iqbal, “Binuclear copper(II) complexes: Synthesis, structural characterization, DNA binding and in silico studies”, J. Serb. Chem. Soc., vol. 85, no. 6, pp. 751-764, Jun. 2020.
Section
Inorganic Chemistry
Author Biographies

Abdul Waheed Kamran, Department of Chemistry, University of Malakand, Chakdara, Dir(L) KPK

student, Department of Chemistry

Saqib Ali, Department of Chemistry Quaid-i-Azam University Islamabad 45320

professor, Department of Chemistry

Muhammad Nawaz Tahir, Department of Physics, University of Sargodha, Sargodha

professor, Department of Physics

Muhammad Zahoor, Department of Chemistry, University of Malakand, Chakdara, Dir(L) KPK

professor, Department of Chemistry

Abdul Wadood, Department of Biochemistry, Abdul Wali Khan University Mardan, KPK

professor, Department of Biochemistry

Muhammad Iqbal, Department of Chemistry, Bacha Khan University Charsadda 24420, KP

Assistant Professor, Department of Chemistry

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