Health impact of commercially cultivated mushroom Agaricus bisporus and wild-growing mushroom Ganoderma resinaceum - a comparative overview

Maja S. Kozarski, Anita S. Klaus, Jovana Đ. Vunduk, Dragica M. Jakovljević, Milka B. Jadranin, Miomir P. Nikšić

Abstract


Health promoting effects of hot water extracts obtained from fruiting bodies of commercially cultivated mushroom Agaricus bisporus (AbHW) and wild-growing mushroom Ganoderma resinaceum (GrHW) originated from Northern Serbia are presented in this research. These abilities were compared in vitro by the prevention of lipid peroxidation (LPx) in the linoleic acid model system, inhibition of angiotensin converting I enzyme (ACE) which can help in the maintenance of a normal blood pressure level and strengthening the ability of the central cholinergic neuron by inhibiting the activity of acetyl­cholin­este­rase (AChE). Cytotoxic activities were observed towards selected human ma­lignant (HeLa and K562) cell lines and normal-human peripheral blood mono­nuclear cells (PBMC). GrHW contained higher phenolics [5.9 g (100 g)-1], inhibition of LPx (EC50=1.07 mg mL-1), ACE (IC50=0.54 mg mL-1) and AChE (IC50=0.37 mg mL-1), and exhibited a significant selectivity in the antitumor action against HeLa (IC50=0.14 mg mL-1) and K562 (IC50=0.11 mg mL-1) cells. AbHW contained higher total protein [6.4 g (100 g)-1], carbohydrate [75.4 g (100 g)-1] and β-glucan [55.1 g (100 g)-1] content and induced signify­cant proliferation of healthy PBMC from 152–116 % at the concentration range of 0.047–0.187 mg mL-1. Тhе difference in the biological activity of extracts provides guidance on their use as a functional food.


Keywords


Hot water extracts; cytotoxicity; enzyme inhibition; lipid peroxidation

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DOI: https://doi.org/10.2298/JSC190930129K

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