Thermo-responsive hydrogels based on poly(N-isopropyl-acrylamide) and hyaluronic acid cross-linked with nanoclays

Ilinka Mirković; Marija S. Nikolić; Sanja Ostojić; Jelena Maletaškić; Zoran Petrović; Jasna Djonlagić

doi:10.2298/JSC200109023M

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Published: Sep 18, 2020

DOI: https://doi.org/10.2298/JSC200109023M

Keywords:

thermo-responsive hydrogels semi-IPN hydrogels nanoclay hyaluronic acid swelling/deswelling kinetics

Ilinka Mirković

Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia

Marija S. Nikolić

Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia

Sanja Ostojić

Institute of General and Physical Chemistry, University of Belgrade, Studentski trg 12–16, Belgrade, Serbia

Jelena Maletaškić

Vinča Institute of Nuclear Sciences, Materials Science Laboratory, University of Belgrade, Belgrade, Serbia

Zoran Petrović

Kansas Polymer Research Center, Pittsburg State University, Pittsburg, KS, 66762, USA

Jasna Djonlagić

Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia

Abstract

Semi-interpenetrating polymer networks (SIPN) based on thermo-responsive poly(N-isopropylacrylamide) (PNIPA) and water-soluble sodium salts of linear hyaluronic acid (Na-HA) were physically cross-linked with synthetic nanoclay (laponite XLG). PNIPA hydrogels with different cross-linking densities and Na-HA concentrations were synthesized by in situ free-radical redox polymerization. The structure and heterogeneity of the semi-IPN hydrogels were examined by SEM and XRD. The content of clay incorporated in the gel was determined by TGA. DSC measurements showed that volume phase transition temperature and its enthalpy varied with the clay and hyaluronic acid content. SIPN hydrogels containing negatively charged polyelectrolyte, Na-HA, exhibited higher Qe and faster deswelling rates than the corresponding PNIPA NC hydrogels. The presence of the anionic Na-HA polymer reduced the storage modulus, indicating a weakening of the hydrogel network structure, especially at lower clay contents. The nanocomposite hydrogels exhibited high tan d values, which increased with increasing Na-HA content.

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[1]

I. Mirković, M. S. Nikolić, S. Ostojić, J. Maletaškić, Z. Petrović, and J. Djonlagić, “Thermo-responsive hydrogels based on poly(N-isopropyl-acrylamide) and hyaluronic acid cross-linked with nanoclays”, J. Serb. Chem. Soc., vol. 85, no. 9, pp. 1197–1221, Sep. 2020.

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Vol. 85 No. 9 (2020)

Section

Polymers

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

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