Synthesis and properties of new fused pyrrolo-1,10-phenanthroline type derivatives Scientific paper

Main Article Content

Maria Cristina Al-Matarneh
https://orcid.org/0000-0001-9299-1347
Irina Rosca
Sergiu Shova
https://orcid.org/0000-0002-1222-4373
Ramona Danac
https://orcid.org/0000-0003-4370-5353

Abstract

New fused pyrrolo-phenanthroline type derivatives were synthesized, in two steps, from 1,10-phenanthroline and evaluated for antimicrobial activity and fluorescence properties. Our synthetic approach involved a 3+2 dipolar-cycloaddition of some selected N-substituted 1,10-phenanthrolin-1-ium ylides, (m)ethoxycarbonyl and cyano (1,2-di)substituted acetylenes and alkenes, res­pect­ively. The structures of compounds were supported by analytical and spec­troscopic data. The molecular structures of four selected compounds have also been also determined by monocrystal XRD analyses. All synthesized com­pounds were then evaluated for their potential antimicrobial activity against Staphylo­coccus aureus ATCC25923, Escherichia coli ATCC25922 and Can­dida albicans ATCC10231. Two of the compounds demonstrated significant activity against the above tested strains.

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How to Cite
[1]
M. C. Al-Matarneh, I. Rosca, S. Shova, and R. Danac, “Synthesis and properties of new fused pyrrolo-1,10-phenanthroline type derivatives: Scientific paper”, J. Serb. Chem. Soc., vol. 86, no. 10, pp. 901-915, Sep. 2021.
Section
Organic Chemistry

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