Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles, and an evaluation of their antimicrobial activities
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Abstract
A new series of hydrazinecarbothioamides 6–9 bearing a 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6–9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiols 10–13, which proved to be axial isomers. The thioethers 14–17 were prepared by alkylation of 10–13 with methyl iodide. All new compounds were characterized by elemental analysis, and IR, UV, 1H-NMR and 13C-NMR spectroscopy. An evaluation for antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Salmonella tiphimurium, Shigella flexneri and Candida albicans was performed.
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[1]
L. I. Socea, G. Saramet, C. Draghici, B. Socea, V. D. Constantin, and M. A. Radu-Popescu, “Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles, and an evaluation of their antimicrobial activities”, J. Serb. Chem. Soc., vol. 80, no. 12, pp. 1461–1470, Dec. 2015.
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Organic Chemistry
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