Synthesis of new derivatives of alepterolic acid via click chemistry Scientific paper

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Xin Jin
Jianguo Cao
Qingjie Zhao
Qi Wang
Hongmei Guo
Haji Akber Aisa
Guozheng Huang


Alepterolic acid is a natural diterpenoid isolated from Aleuritopteris argentea (S. G. Gmél.) Fée, a fern with potential medicinal activity, used in China as a folk medicine to regulate menstruation and prevent cancer. Never­theless, there are few reports about the structural modification of this natural product. With the wide application of 1,2,3-triazole derivatives in medicines, pesticides, functional materials, the synthesis of 1,2,3-triazoles derivatives has attracted the attention of synthetic chemists. In this article, 23 new derivatives of alepterolic acid combined with 1,2,3-triazole were designed and synthesized by esterific­ation and click chemistry reaction in a fast, conventional and effi­cient way. All the products were obtained in good yields (72 to 97 %). The structure of these compounds was confirmed by 1H-, 13C-NMR and mass spec­tral data. The use of the easily available reactants and the common reaction conditions furnish an efficient method for the synthesis of alepterolic acid deri­vatives. The preparation of these compounds would enable further biological evaluation in the future.

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How to Cite
X. Jin, “Synthesis of new derivatives of alepterolic acid via click chemistry: Scientific paper”, J. Serb. Chem. Soc., vol. 86, no. 10, pp. 917-925, Sep. 2021.
Organic Chemistry


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