Thermoanalytical and spectroscopic studies on medicated jellies with perphenazine Scientific paper

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Published: Apr 21, 2024
Updated: 21.04.2024
DOI: https://doi.org/10.2298/JSC230402077B
Keywords:
antipsychotic drug pharmaceutical formulations thermal properties biocompatible polymers biopolymers gelling agents

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Mihaela Budiul
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115 Timișoara, România; West University of Timisoara – ICAM – Advanced Environmental Research Institute
https://orcid.org/0000-0002-0958-4992
Madalina Mateescu
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115 Timișoara, România;
https://orcid.org/0000-0001-8313-5055
Gabriela Vlase
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115 Timișoara, România; 2West University of Timisoara – ICAM – Advanced Environmental Research Institute
https://orcid.org/0000-0002-1307-7010
Titus Vlase
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115 Timișoara, România; West University of Timisoara – ICAM – Advanced Environmental Research Institute
https://orcid.org/0000-0002-7480-7486
Simona Bocanici
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115 Timișoara, România;
https://orcid.org/0009-0008-8627-7305
Ionela Bradu
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115 Timișoara, România;
https://orcid.org/0009-0005-8738-3642

Abstract

Medicated jellies are widely used by a large part of patients, espe­cially by people with swallowing difficulties. Preformulation studies play an essential role in the development of new pharmaceutical formulations. The pre­sent study aimed to formulate and evaluate medicated jellies containing per­phenazine, an antipsychotic drug from the group of phenothiazine compounds used to treat schizophrenia and other mental disorders. Typical gelling agents such as sodium alginate (Alg), gelatine (Gel), and pectin (Pec) were used to develop the medicated jellies. In addition to the biopolymers, components such as benzoic acid (BenzAc), citric acid (CitAc), sodium citrate (NaCit), sorbitol (Sorb) and xylitol (Xyl) were also used. Before preparing the jellies, the moist binary mixture between each component of the jelly and the active substance was analysed to investigate the compatibility of the substances. The active sub­stance, moist binary mixture, and medicated jellies were analysed by FTIR_UATR spectroscopy, UV–Vis spectroscopy and thermogravimetry.

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[1]
M. Budiul, M. Mateescu, G. Vlase, T. Vlase, S. Bocanici, and I. Bradu, “Thermoanalytical and spectroscopic studies on medicated jellies with perphenazine: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 4, pp. 521–537, Apr. 2024.
Issue
Vol. 89 No. 4 (2024)
Section
Physical Chemistry
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