Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones Scientific paper

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Burcu Karayavuz
https://orcid.org/0000-0001-9631-2575
Siva Krishna Vagolu
Didem Kart
Tone Tønjum
https://orcid.org/0000-0002-1709-6921
Oya Unsal-Tan
https://orcid.org/0000-0002-4152-069X

Abstract

This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5aj and 6af, to test for their antimyco­bacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H- and 13C-NMR). Amongst the compounds tested, 5e, 5g, 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis.

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[1]
B. . Karayavuz, S. K. Vagolu, D. Kart, T. Tønjum, and O. Unsal-Tan, “Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 11, pp. 1423–1431, Dec. 2024.
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Biochemistry & Biotechnology

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