Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones Scientific paper

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Published: Dec 5, 2024
Updated: 05.12.2024
DOI: https://doi.org/10.2298/JSC230424040K
Keywords:
pyridazinone furan biological activity

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Burcu Karayavuz
Department of Pharmaceutical Chemistry, Faculty of Farmacy, Hacettepe University, Ankara, Turkey
https://orcid.org/0000-0001-9631-2575
Siva Krishna Vagolu
Unit for Genome Dynamics, Department of Microbiology, University of Oslo, Oslo, Norway
Didem Kart
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
Tone Tønjum
Unit for Genome Dynamics, Department of Microbiology, University of Oslo, Oslo, Norway
https://orcid.org/0000-0002-1709-6921
Oya Unsal-Tan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100, Ankara, Turkey
https://orcid.org/0000-0002-4152-069X

Abstract

This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a–j and 6a–f, to test for their antimyco­bacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H- and 13C-NMR). Amongst the compounds tested, 5e, 5g, 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis.

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[1]
B. . Karayavuz, S. K. Vagolu, D. Kart, T. Tønjum, and O. Unsal-Tan, “Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 11, pp. 1423–1431, Dec. 2024.
Issue
Vol. 89 No. 11 (2024)
Section
Biochemistry & Biotechnology
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