Chlorogenic acid with cytotoxic activity and other constituents from Anacyclus valentinus from Algeria
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Abstract
Anacyclus valentinus is a Saharan plant belonging to the Asteraceae family. This study identified and determined the structure of isolated compounds obtained from crude extract of A. valentinus. Their cytotoxic effects on two human cancer cell lines were examined. The extract of the aerial part of A. valentinus was fractioned by Solid Phase Extraction (SPE). The fractions obtained were analyzed by (NMR) spectroscopy and HPLC-DAD-MS. This is the first cytotoxic investigation of A. valentinus. The extracts of the plant were prepared, and their cytotoxic effects on two human cancer cell lines (A549, human lung adenocarcinoma; HepG2, hepatocellular carcinoma) were examined using the MTT assay. Several compounds have been identified. The results illustrated two newly identified compounds: chlorogenic acid and the β-glucosides derivative. In addition, C-glycosides (2 isomers of apigenin) were detected in the genus Anacyclus. The IC50 values of crude extracts of the aerial parts of A. valentinus against the A549 cell line were determined as 19.79 µg/mL. The values for the HepG2 cell line were 32.63 µg/mL. Chlorogenic acid was showed the highest cytotoxic activities on the A549 and HepG2 cell lines with IC50 values of 13.59 and 12.84 μg/mL, respectively.
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