Optimisation of the controlled release of valsartan via cellulose acetate butyrate and poly(butylene succinate) microspheres: Influence of formulation conditions Scientific paper

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Published: Nov 17, 2025
Updated: 17.11.2025
DOI: https://doi.org/10.2298/JSC250521068B
Keywords:
microencapsulation polymers carriers formulation conditions controlled release valsartan

Main Article Content

Aissa Bouharaoua
Laboratory of Macromolecular Physical and Organic Chemistry, Faculty of Exact Sciences, University of Djillali Liabes, Sidi Bel-Abbes, Algeria
https://orcid.org/0009-0004-7681-6943
Haouaria Merine
Laboratory of Macromolecular Physical and Organic Chemistry, Faculty of Exact Sciences, University of Djillali Liabes, Sidi Bel-Abbes, Algeria
https://orcid.org/0000-0001-9640-9684
Youssef Ramli
Laboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
https://orcid.org/0000-0002-6885-5692

Abstract

This study investigates the formulation of valsartan-loaded cellulose acetate butyrate (CAB) microspheres, prepared via solvent evaporation micro­encapsulation, to evaluate their in vitro release behavior and the influence of formulation parameters. The study examined the effects of stirring speed, stab­ilizers and matrix materials on particle size and drug release. Increasing stirring speed reduced particle size but also led to higher valsartan loss, reducing encapsulation efficiency. Using the surfactant polylactic acid resulted in smooth, spherical and porous microspheres that enhanced controlled release. In contrast, using Tween 80 led to irregular particles with rough surfaces and larger pores that accelerated drug release. Including poly(butylene succinate) in the matrix resulted in smaller microparticles forming and a significantly higher rate of valsartan release. These findings emphasize the importance of opti­mizing formulation parameters and excipients to control drug release character­istics and enhance drug delivery system performance.

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How to Cite
[1]
A. Bouharaoua, H. Merine, and Y. Ramli, “Optimisation of the controlled release of valsartan via cellulose acetate butyrate and poly(butylene succinate) microspheres: Influence of formulation conditions: Scientific paper”, J. Serb. Chem. Soc., vol. 90, no. 11, pp. 1331–1352, Nov. 2025.
Issue
Vol. 90 No. 11 (2025)
Section
Polymers
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Author Biography

Haouaria Merine, Laboratory of Macromolecular Physical and Organic Chemistry, Faculty of Exact Sciences, University of Djillali Liabes, Sidi Bel-Abbes, Algeria

department oh chemisty , 

Faculty of Exact Sciences, DjilaliLiabes Universty, BP89 City El Arbi
Ben m hidiSidi Bel-Abbes, ALGERIA

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