Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives

Kulathooran Singaram; Dhamodaran Marimuthu; Selvakumar Baskaran; Venkataraman Ramaswamy

doi:10.2298/JSC151112043S

PDF (2,064 kB) Supplementary Material (2.16 MB)

Published: Sep 1, 2016

DOI: https://doi.org/10.2298/JSC151112043S

Keywords:

N-arylsulfonyl-3 5-diarylidene-4-piperidone N-alkylcarbonyl-3 5-di-arylidene-4-piperidone crotonisation antimicrobial activity.

Kulathooran Singaram

Research & Development Centre, Bharathiar University, Coimbatore-641046

Dhamodaran Marimuthu

Department of Chemistry, Perunthalaivar Kamarajar Institute of Engineering and Technology, Karaikal-609603

Selvakumar Baskaran

Department of Chemistry, PG and Research Centre, Sriparamakalyani College, Alwarkurichi 627412

Venkataraman Ramaswamy

Department of Chemistry, PG and Research Centre, Sriparamakalyani College, Alwarkurichi 627412

Abstract

Three series of heteroaromatic analogs (twenty seven compounds) with monoketone linkers have been synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)piperidin-4-one 5e showed best antifungal activity against Aspergillus niger and Aspergillus fumigatus. Structural elucidation of the synthesized compounds was determined on the basis of various spectroscopic methods.

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How to Cite

[1]

K. Singaram, D. Marimuthu, S. Baskaran, and V. Ramaswamy, “Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives”, J. Serb. Chem. Soc., vol. 81, no. 8, pp. 859–870, Sep. 2016.

Issue

Vol. 81 No. 8 (2016)

Section

Organic Chemistry

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Kulathooran Singaram, Research & Development Centre, Bharathiar University, Coimbatore-641046

Research scholar, Department of Chemistry

Dhamodaran Marimuthu, Department of Chemistry, Perunthalaivar Kamarajar Institute of Engineering and Technology, Karaikal-609603

Professor, Head of the Department, Department of Chemistry

Selvakumar Baskaran, Department of Chemistry, PG and Research Centre, Sriparamakalyani College, Alwarkurichi 627412

Research Scientist, Department of Chemistry

Venkataraman Ramaswamy, Department of Chemistry, PG and Research Centre, Sriparamakalyani College, Alwarkurichi 627412

Professor, Department of Chemistry

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