Investigation into the potential chemical mechanism of carotenoids pro-oxidant activity with liposomes under UV- irradiation
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Abstract
This study focuses on the behavior of β-carotene and lutein inside multilamellar liposomes under continuous UV-irradiation. Liposomes were obtained by thin film method and carotenoids (Crts) were incorporated by mixing method at various concentrations (0.005, 0.0075, 0.02, 0.07 and 0.5 mol%). Liposomes formation and presence of Crts inside them were confirmed by SEM microscopy and FT-IR spectroscopy, respectively. The antioxidant/prooxidant activity of Crts inside liposomes was determined by Thiobarbituric Acid – Malondialdehyde (TBA-MDA) test. Investigated Crts act more or less unexpected (as pro-oxidants) inside lipid bilayer, interacting with UV-produced lipid radicals and suffering under UV-irradiation in the same time. Their pro-oxidant activity, with liposomes and under UV-irradiation, can be explained by unstable adducts formation in reaction with peroxyl radicals, or by Crts-cation radicals formation via electron transfer mechanism. Such tentatively unexpected behavior of carotenoids should be taken into account in further carotenoids based UV-filters projections in cosmetic formulation for skin protection.
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References
W. Miki, Pure Appl. Chem. 63 (1991) 141
P. Palozza, N. Krinsky, Methods Enzymol. 213 (1992) 403
H. Tatsuzawa, T. Maruyama, N. Misawa, K. Fujimori, M. Nakano, FEBS Lett. 484 (2000) 280
M. A. Montenegro, M. A. Nazareno, E. N. Durantini, C. D. Borsarelli, Photochem. Photobiol. 75 (2002) 353
W. Stahl, H. Sies, Mol. Aspects Med. 24 (2003) 345
G. Burton, K. Ingold, Science 224 (1984) 569
B. Peng Lim, A. Nagao, J. Terao, K. Tanaka, T. Suzuki, , K. Takama, Biochim. Biophys. Acta 1126 (1992) 178
A. Woodall, G. Britton, M. Jackson, Biochim. Biophys. Acta 1336 (1997) 575
R. Edge, T. G. Truscott, Spectrum 13 (2000) 12
N. Krinsky, K. Yeum, Biochem. Biophys. Res. Commun. 305 (2003) 754
M. Carocho, I. Ferreira, Food Chem. Toxicol. 51 (2013) 15
I. Nikbakht-Jam, M. Khademi, M. Nosrati, S. Eslami, M. Foroutan-Tanha, A. Sahebkar, S. Tavalaie, M. Ghayour-Mobarhana, G. Fernse, F. Hadizadehf, S. Sajjadi Tabasig, S. Mohajerig, M. Emamiana, Eur. J. Integr. Med. 8 (2016) 307
K. Haila, PhD Thesis, University of Helsinki, Department of Applied Chemistry and Microbiology, Helsinki, Finland, 1999
A. El-Agamey, G. M. Lowe, D. J. McGarvey, A. Mortensen, D. M. Phillip, T. G. Truscott, A. J. Young, Arch. Biochem. Biophys. 430 (2004) 37
A. J. Young, G. M. Lowe, Arch. Biochem. Biophys. 385 (2001) 20
P. Palozza, Biochim. Biophys. Acta 1740 (2005) 215
A. Subagio, N. Morita, Food Res. Int. 34 (2001)183
A. Subagio, N. Morita, Food. Chem. 81 (2003) 97
J. Fiedor, L. Fiedor, R. Haeßner, H. Scheer, Biochim. Biophys. Acta 1709 (2005) 1
J. Fiedor, L. Fiedor, J. Winkler, A. Scherz, H. Scheer, Photochem. Photobiol. 74 (2001) 64
M. Havaux, Plant J. 79 (2013) 597
F. Ramel, S. Birtic, C. Ginies, L. Soubigou-Taconnat, C. Triantaphylidès, M. Havaux, Proc. Natl. Acad. Sci. U.S.A. 109 (14) (2012) 5535
F. Ramel, S. Birtic, S. Cuine, C. Triantaphylides, J.-L. Ravanat, M. Havaux, Plant Physiol. 158 (2012) 1267
S. Vemuri, C. T. Rhodes, Pharm. Acta Helv. 70 (1995) 95
D. Marković, L. Patterson, Photochem. Photobiol. 58 (1993) 329
R. Wheatley, Trends Anal. Chem. 19 (2000) 617
A. Girotti, J. Photochem. Photobiol., B 63 (2001) 103
C. Choi, S. Kim, S. Hwang, B. Choi, H. Ahn, M. Lee, S. Park, S. Kim, Plan. Sci. 163 (2002) 1161
R. Lewis, R. N. McElhaney, Chem. Phys. Lipids 96 (1998) 9
F. Korkmaz, F. Severcan, Arch. Biochem. Biophys. 440 (2005) 141
Y. Er, C. A. Prestidge, D. Fornasiero, Colloids Surfaces, B 36 (2004) 147
B. Biruss, R. Dietl, C. Valenta, Chem. Phys. Lipids 148 (2007) 84
J. Giri, S. G. Thakurta, J. Bellare, A. K. Nigam, D. Bahadura, J. Magn. Magn. Mater. 293 (2005) 62
A. Sujak, J. Gabrielska, J. Milanowska, P. Mazurek, K. Strzalka, W. I. Gruszecki, Biochim. Biophys. Acta 1712 (2005) 17
A. Sujak, M. Gagos, M. Dalla Serra, W. I. Gruszecki, Mol. Membr. Biol. 24 (2007) 431
M. Herec, A. Islamov, A. Kuklin, M. Gagos, W. I. Gruszecki, Chem. Phys. Lipids 147 (2007) 78
V. Stefov, B. Šoptrajanov, F. Spirovski, I. Kuzmanovski, H. D. Lutz, B. Engelen J. Mol. Struct. 689 (2004) 1
A. Cahil, B. Šoptrajanov, M. Najdoski, H. D. Lutz, B. Engelen, V. Stefov, J. Mol. Struct. 876 (2008) 255
G. W. Burton, J. Nutr. 119 (1989) 109
G. Britton, FASEB J. 9 (1995) 1551
P. Palozza, Nutr. Rev. 56 (1998) 257
T. A. Kennedy, D. C. Liebler, Chem. Res. Toxicol. 4 (1991) 290
T. A. Kennedy, D. C. Liebler, J. Biol. Chem. 267 (1992) 4658
R. Edge, D. J. McGarvey, T. G. Truscott, J. Photochem. Photobiol., B 41 (1997) 189
A. Takahashi, N. Shibasaki-Kitakawa, T. Yonemoto, J. Am. Oil Chem. Soc. 76 (1999) 897
H. Tsuchihashi, M. Kigoshi, M. Iwatsuki, E. Niki, Arch. Biochem. Biophys. 323 (1995) 137
A. Mortensen, L. H. Skibsted, T. G. Truscott, Arch. Biochem. Biophys. 385 (2001) 13
A. Mortensen, L. H. Skibsted, FEBS Lett. 426 (1998) 392
M. Heinonen, K. Haila, A–M. Lampi, V. Piironen, J. Am. Oil Chem. Soc. 74 (1997) 1047
M. N. Sarbolouki, P. M. Bagheri, V. Saneei, Daru, J. Pharm. Sci. 13 (2005) 148
N. I. Krinsky, S. M. Deneke, J. Natl. Cancer Inst. 69 (1982) 205
H. D. Martin, C. Ruck, M. Schmidt, S. Sell, S. Beutner, B. Mayer, R. Walsh, Pure Appl. Chem. 71 (1999) 2253
T. Y. P. Bonnie, Y. M. Choo, J. Palm Oil Res. 1 (1999) 62
M. Carail, C. Caris-Veyrat, Pure Appl. Chem. 78 (2006) 1493
J. Rontani, Photochemistry 58 (2001) 187
M. Wrona, W. Korytowski, M. Rozanowska, T. Sarna, T. G. Truscott, Free Radical Biol. Med. 35 (2003) 1319
B. Halliwell, S. Chirico, Am. J. Clin. Nutr. 57 (1993) 715
D. Rengel, A. Díez-Navajas, A. Serna-Roco, P. Veiga, A. Muga, J. C. Milicua, Biochim. Biophys. Acta 1463 (2000) 179
L. Tang, Y. Zhang, Z. Qian, X. Shen, Biochem. J. 352 (2000) 27
D. Cvetković, D. Z. Marković, J. Serb. Chem. Soc. 73 (2008) 15
D. Cvetković, D. Z. Marković, J. Serb. Chem. Soc. 72 (2007) 235
D. Cvetković, D. Z. Marković, Radiat. Phys. Chem. 77 (2008) 34
D. Cvetković, D. Z. Marković, Radiat. Phys. Chem. 80 (2011) 76
D. Cvetković, D. Z. Marković, Russ. J. Phys. Chem. A 86 (2012) 763
D. C. Liebler, T. D. McClure, Chem. Res. Toxicol. 9 (1996) 8
M. Burke, R. Edge, E. J. Land, T. G. Truscott, J. Photochem. Photobiol., B 60 (2001) 1
Y. Matsushita, R. Suzuki, E. Nara, A. Yokoyama, K. Miyashita, Fish. Sci. (Tokyo, Jpn.) 66 (2000) 980.