Investigation into the potential chemical mechanism of carotenoids pro-oxidant activity with liposomes under UV- irradiation

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Dragan Jovan Cvetković
Jelena Stanojević
Milorad Cakić
Dejan Marković

Abstract

This study focuses on the behavior of β-carotene and lutein inside multilamellar liposomes under continuous UV-irradiation. Liposomes were obtained by thin film method and carotenoids (Crts) were incorporated by mixing method at various concentrations (0.005, 0.0075, 0.02, 0.07 and 0.5 mol%). Liposomes formation and presence of Crts inside them were confirmed by SEM microscopy and FT-IR spectroscopy, respectively. The antioxidant/prooxidant activity of Crts inside liposomes was determined by Thiobarbituric Acid – Malondialdehyde (TBA-MDA) test. Investigated Crts act more or less unexpected (as pro-oxidants) inside lipid bilayer, interacting with UV-produced lipid radicals and suffering under UV-irradiation in the same time. Their pro-oxidant activity, with liposomes and under UV-irradiation, can be explained by unstable adducts formation in reaction with peroxyl radicals, or by Crts-cation radicals formation via electron transfer mechanism. Such tentatively unexpected behavior of carotenoids should be taken into account in further carotenoids based UV-filters projections in cosmetic formulation for skin protection.

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How to Cite
[1]
D. J. Cvetković, J. Stanojević, M. Cakić, and D. Marković, “Investigation into the potential chemical mechanism of carotenoids pro-oxidant activity with liposomes under UV- irradiation”, J. Serb. Chem. Soc., vol. 82, no. 9, pp. 1009–1023, Sep. 2017.
Section
Biochemistry & Biotechnology

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