Highly invasive alien plant Reynoutria japonica Houtt. represents a novel source for pharmaceutical industry – evidence from phenolic profile and biological activity

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Biljana Božin
Marjana Gavrilović
Nebojša Kladar
http://orcid.org/0000-0001-5781-6412
Milica Rat
Goran Anačkov
Neda Gavarić

Abstract

Reynoutria japonica is on the IUCN list of the Worlds100 worst invasive species, but it is also, especially its rhizome, an integral part of Traditional Chinese Medicine. The objective of this study was to determine the amount of selected phenolic compounds in rhizome, stems, leaves and inflorescence methanol extracts of this plant, their antioxidant and anticholinesterase activity. The chemical profile of the examined extracts was obtained by a high-performance liquid chromatography. In vitro assays on DPPH, OH and NO radicals were used to estimate antioxidant potential and Ellmans method was applied for the determination of anticholinesterase activity. Leaves and rhizome extracts were found to be rich in rosmarinic and chlorogenic acid, and selected flavonoids. Resveratrol was exclusively present in rhizome and stems extracts. All the investigated extracts expressed certain antioxidant activity, where leaves extract was the most active. However, rhizome extract was the strongest inhibitor of acetylcholinesterase. These findings indicate that there is a possibility of R. japonica exploitation for the isolation of biologically active phenolic compounds used in pharmaceutical and food industry.

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How to Cite
[1]
B. Božin, M. Gavrilović, N. Kladar, M. Rat, G. Anačkov, and N. Gavarić, “Highly invasive alien plant Reynoutria japonica Houtt. represents a novel source for pharmaceutical industry – evidence from phenolic profile and biological activity”, J. Serb. Chem. Soc., vol. 82, no. 7-8, pp. 803–813, Aug. 2017.
Section
Biochemistry & Biotechnology
Author Biographies

Biljana Božin, University of Novi Sad, Faculty of Medicine, Hajduk Veljkova 3, 21000 Novi Sad

Department of Pharmacy

Marjana Gavrilović, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovića 3, 21000 Novi Sad

Department of Biology and Ecology

Nebojša Kladar, University of Novi Sad, Faculty of Medicine, Hajduk Veljkova 3, 21000 Novi Sad

Department of Pharmacy

Milica Rat, University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovića 3, 21000 Novi Sad

Department of Biology and Ecology

Neda Gavarić, University of Novi Sad, Faculty of Medicine, Hajduk Veljkova 3, 21000 Novi Sad

Department of Pharmacy

References

P. Stypinski, Fragm. Florist. Geobot. 23 (1997) 316

P. Pyšek, K. Prach, In Ecosystem Management, Springer, Berlin, 1993, p. 254

I. Trinajstić, J. Franjić, D. Kajba, Acta Bot. Croat. 53 (1994) 145

B. Mandak, P. Pysek, K. Bimova, Preslia 76 (2004) 15

S. Lowe, M. Browne, S. Boudjelas, M. De Poorter, 100 of the worlds worst invasive alien species: a selection from the global invasive species database, Invasive Species Specialist Group (ISSG) a specialist group of the Species Survival Commission (SSC) of the World Conservation Union (IUCN), 2000

A. W. Sheppard, R. H. Shaw, R. Sforza, Weed Res. 46 (2006) 93

M. Glavendekić, Šumarstvo 60 (2008) 67

W. Peng, R. Qin, X. Li, H. Zhou, J. Ethnopharmacol. 148 (2013) 729

K. W. Kim, K. T. Ha, C. S. Park, U. H. Jin, H. W. Chang, I. S. Lee, C. H. Kim, Vascul. Pharmacol. 47 (2007) 99

J. Burns, T. Yokota, H. Ashihara, M. E. Lean, A. Crozier, J. Agric. Food Chem. 50 (2002) 3337

W. Chun-Fu, Y. Jing-Yu, W. Fang, W. Xiao-Xiao, Chin. J. Nat. Med. 11 (2013) 1

F. Li, Z. Zhan, F. Liu, Y. Yang, L. Li, Z. Feng, J. Jiang, P. Zhang, Org. Lett. 15 (2013) 674

A. Y. Sun, A. Simonyi, G. Y. Sun, Free Radical Biol. Med. 32 (2002) 314

N. S. Lakic, N. M. Mimica-Dukic, J. M. Isak, B. N. Bozin, Cent. Eur. J. Biol. 5 (2010) 331

A. Ziaková, E. Brandšteterová, J. Liq. Chromatogr. Relat. Technol. 26 (2003) 443

R. Pezet, V. Pont, P. Cuenat, J. Chromatogr. 663 (1994) 191

B. Bozin, N. Mimica-Dukic, N. Simin, G. Anackov, J. Agric. Food Chem. 54 (2006) 1822

B. Bozin, N. Kladar, N. Grujic, G. Anackov, I. Samojlik, N. Gavaric, B. S. Conic, Molecules 18 (2013) 11733

G. L. Ellman, K. D. Courtney, V. Andres, Jr., R. M. Feather-Stone, Biochem. Pharmacol. 7 (1961) 88

N. Kladar, B. Srđenović, N. Grujić, B. Bokić, M. Rat, G. Anačkov, B. Božin, Braz. J. Bot. 38 (2015) 703

H. W. Lin, M. X. Sun, Y. H. Wang, L. M. Yang, Y. R. Yang, N. Huang, L. J. Xuan, Y. M. Xu, D. L. Bai, Y. T. Zheng, K. Xiao, Planta Med. 76 (2010) 889

Y. W. Lin, F. J. Yang, C. L. Chen, W. T. Lee, R. S. Chen, J. Nat. Med. 64 (2010) 146

V. Marques, A. Farah, Food Chem. 113 (2009) 1370

A. Farah, C. M. Donangelo, Braz. J. Plant Phys. 18 (2006) 23

H. J. Lee, H. S. Cho, E. Park, S. Kim, S. Y. Lee, C. S. Kim, D. K. Kim, S. J. Kim, H. S. Chun, Toxicology 250 (2008) 109

Z. Kuznetsova, Seryya Biyalagichnykh Navuk, Vestsi Akademii Navuk Belarusi, Vol. 5, 1979, p. 29

S. Kumar, A. K. Pandey, Sci. World J. (2013) 162750

H. Temsamani, S. Krisa, J.-M. Mérillon, T. Richard, J. Nutr. Health Aging 3 (2015) 49

L. Bavaresco, C. Fregoni, E. Cantu, M. Trevisan, Drugs Exp. Clin. Res. 25 (1998) 57

N. Vrchotova, B. Sera, J. Triska, Acta Chromatogr. 19 (2007) 21

J. E. Klaunig, L. M. Kamendulis, Ann. Rev. Pharmacol. Toxicol. 44 (2004) 239

J. Shan-Hua, J. Guang-Shi, Z. Xing-Shan, Chin. J. Med. 9 (2009) 453

D. Jin-Liang, J. Rui, C. Li-Ping, Y. Guo-Jun, Acta Agric. Univ. Jiangxi 5 (2012) 27

A. Gella, N. Durany, Cell Adh. Migr. 3 (2009) 88

M. B. Colovic, D. Z. Krstic, T. D. Lazarevic-Pasti, A. M. Bondzic, V. M. Vasic, Curr. Neuropharmacol. 11 (2013) 315.