Multicomponent synthesis of the new bispyranpyrazole and their antimicrobial-antioxidant evaluations

Mohamad Yusuf, Saloni Thakur

Abstract


The one pot three component reactions have been utilized to obtain a series of new symmetrical bispyranopyrazoles built around the six rigid linkers in good yields and in the short durations under the normal conditions. The structures of the prepared compounds were characterized by using their IR, 1H-NMR, 13C-NMR and ESI-MS spectral parameters. The bispyranopyrazoles 3b and 3f exhibited the significant antimicrobial action against Klebsiella pneumonia, Fusarium oxysporum and Penicillium glabrum at MIC 3.12 µg/mL which is equivalent to MIC of standard drug. Trans-butene linked bispyranopyrazole 3f also associated with good radical scavenging activity like ascorbic acid (standard antioxidant).


Keywords


pyrazole; dibenzaldehydes; rigid chain linkers; atom economy; antimicrobial activity; antioxidant property

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DOI: https://doi.org/10.2298/10.2298/JSC171107074Y

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