Multicomponent synthesis of new bis(pyranopyrazoles) and their antimicrobial–antioxidant evaluations

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Mohamad Yusuf
Saloni Thakur

Abstract

One-pot, three-component reactions were utilized to obtain a series of new symmetrical bis(pyranopyrazoles) built around six rigid linkers in good yields and in the short durations under normal conditions. The structures of the prepared compounds were confirmed using their IR, 1H-NMR, 13C-NMR and ESI-MS spectral parameters. The bis(pyranopyrazoles) 3b and 3f exhibited significant anti­microbial action against Klebsiella pneumoniae, Fusarium oxysporum and Penicil­lium glabrum at a minimum inhibitory concentration (MIC) value of 3.12 µg mL-1, which is equivalent to the MIC of the standard drug. trans-Butene-linked bis(pyranopyrazole) 3f was also associated with a good radical scavenging activity similar to that of ascorbic acid (a standard antioxidant).

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How to Cite
[1]
M. Yusuf and S. Thakur, “Multicomponent synthesis of new bis(pyranopyrazoles) and their antimicrobial–antioxidant evaluations”, J. Serb. Chem. Soc., vol. 84, no. 2, pp. 119–128, Mar. 2019.
Section
Organic Chemistry
Author Biographies

Mohamad Yusuf, Department of Chemistry, Punjabi University, Patiala-147002, Punjab

Associate Professor of Organic Chmeistry, Department of Chemistry, Punjabi University, Patiala-147002, Punjab, India

Saloni Thakur, Department of Chemistry, Punjabi University, Patiala-147002, Punjab

Ph. D. student, Department of Chemistry, Punjabi University, Patiala-147002, Punjab, India

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