Studies on the chemical compositions of Hyptis suaveolens (L.) Poit.

Gengqiu Tang, Xile Liu, Xue Gong, Xiaojing Lin, Xiudi Lai, Dong Wang, Shengguo Ji

Abstract


This study aimed at identifying the chemical compounds isolated from the aerial parts and roots of Hyptis suaveolens (L.) Poit. The compounds were iso­lated and purified by a combination of various chromatographic techniques inc­luding silica gel column chromatography, silica gel reverse phase column chro­ma­tography, Sephadex LH-20 gel column chromatography, semi-prepar­ative HPLC and recrystallization. The chemical structures were analyzed and elu­cid­ated based on physiochemical properties and spectroscopic analysis. From the aerial parts of H. suaveolens, eight compounds were isolated and identified as quercetin 3-O-β-d-glucopyranoside (1), apigenin (2), sorbi­folin (3), quercetin (4), kaempferol (5), genkwanin (6), rosmarinic acid (7) and methyl rosmarinate (8). Two compounds were isolated from the roots of H. suaveolens and identified as podophyllotoxin (9) and picropodophyllotoxin (10). Compounds 26 were isolated from H. suaveolens for the first time while compound 10 was isolated from the genus of Hyptis for the first time. The results of this study provided a scientific basis for the development of the medi­cinal value of H. suaveolens and have important theoretical significance for the chemical utilization of H. suaveolens resources.


Keywords


structural identification; quercetin 3-O-β-D-glucopyranoside; sorbifolin

References


M. R. Henderson, Malayan Wild Flowers (Dicotyledones), Tien Wah Press Ltd., Singapore, 1959, p. 476

C. A. Backer, R. C. B. Van de Brink, Jr., Flora of Java, N.V.P. Noordhoff, Graningen, 1965, p. 630

K. R. Kiritikar, B. D. Basu, Indian medicinal plant: International Book Distributers, Vol. II, Booksellers and Publishers, Chennai, 1999, p. 852

S. Mahesh, A, Chatterjee, S. C. Pakrashi, The Treatise on Indian Medicinal Plants, PID, New Delhi, 2001, p. 1

O. T. Asekun, O. Ekundayo, B. A. Adeniyi, Fitoterapia 70 (1999) 440

M. J. Oliveira, I. F. P. Campos, C. B. A. Oliveira, M. R. Santos, P. S. Souza, S. C. Santos, J. C. Seraphin, P. H. Ferri, Biochem. Syst. Ecol. 33 (2005) 275

M .M. R. Kansole, A. Hilou, J. F. Millogo, O. G. Nacoulma, Am. J. Ethnomed. 2 (2015) 4

K. Pålsson, T. G. Jaenson, Acta Trop. 72 (1999) 39

A. Seyoum, K. Palsson, S. Kung'a, E. W. Kabiru, W. Lwande, G. F. Killeen, A. Hassanali, B. G. J. Knols, Trans. R. Soc. Trop. Med. Hyg. 96 (2002) 225

I. O. Ebenezer, Global J. Health Sci. 3 (2011) 84

K. Hasan, A. A. Naser, S. Sabiha, M. Nesa, M. Khan, N. Islam, J. Entomol. Zool. Stud. 6 (2018) 785

P. Mozhiyarasi, R. Anuradha, J. Chem. Pharm. Res. 8 (2016) 438

M. Chatri, A. Baktiar, Mansyurdin, P. Adnadi, Am. J. Res. Commun. 2 (2014) 30

A. C. P. Moreira, E. D. O. Lima, P. A. Wanderley, E. S. Carmo, E. L. D. Souza, Braz. J. Microbiol. 41 (2010) 28

A. O. Eshilokun, A. A. Kasali, A. O. Giwa-Ajeniy, Flavour Fragrance J. 20 (2005) 528

J. P. Noudogbessi, P. Agbangnan, B. Yehouenou, E. Adjalian, G. Nonviho, M. Akibou-

-Osseni, V. Wotto, G. Figueredo, J. C. Chalchat, D. Sohounhloue, Int. J. Med. Arom. Plants 3 (2013) 191

T. C. Santos, M. S. Marques, I. A. C. Menezes, K. S. Dias, A. B. L. Silva, I. C. M. Mello, A. C. S. Carvalho, S. C. H. Cavalcanti, A. R. Antoniolli, R. M. Marçal, Fitoterapia 78 (2007) 333

J. W. A. Bezerra, A. R. Costa, M. A. P. da Silva, M. I. Rocha, A. A. Boligon, J. B. T. da Rocha, L. M. Barros, J. P. Kamdem, S. Afr. J. Bot. 113 (2017) 437

Z. Zhou, C. Yang, Acta Bot. Yunnanica 22 (2000) 343

R. H. Mao, Z. H. Zhong, W. U. Wen-Ming, Y. Liu, R. Han-Li, Chin. Tradit. Herb. Drugs 47 (2016) 2236

Y. M. Hu, Z. L. Du, H. Wang, W. C. Ye, S. Z. Zhao, China J. Chin. Mater. Med. 32 (2007) 603

Y. L. Li, K. M. Li, M. X. Su, K. T. Leung, Y. W. Chen, Y. W. Zhang, China J. Chin. Mater. Med. 31 (2006) 397

L. H. Zhang, Z. Q. Yin, W. C. Ye, S. X. Zhao, L. Wang, F. Hu, China J. Chin. Mater. Med. 30 (2005) 1522

S. M. Pan, H. Y. Ding, W. L. Chang, H. C. Lin, Chin. Pharm. J. 58 (2006) 35

Y. Tezuka, R. Kasimu, J. X. Li, P. Basnet, K. Tanaka, T. Namba, S. Kadota, Chem. Pharm. Bull. 46 (1998) 107

L. Z. Lin, PhD Thesis, South China University of Technology, Guangzhou, 2013

Y. G. Chen, L. F. Zhang, Y. C. Liu, B. S. Wang, X. Jin, X. T. Fu, J. P. Zhou, H. Z. Guo, Chin. Tradit. Herbal. Drugs 41 (2010) 1619

A. S. Feliciano, J. M. M. D. Corral, M. Gordaliza, M. A. Castro, Magn. Reson. Chem. 31 (2011) 868

N. T. Ekow, K. Dzobo, F. Adu, S. Chirikure, A. Wonkam, C. Dandara. J. Ethnopharmacol. 211 (2018) 58

S. Prawatsri, A. Suksamrarn, A. Chindaduang, T. Rukachaisirikul, Chem. Biodiversity. 10 (2013) 1494

E. Lautié, R. Quintero, J. Ethnopharmacol. 120 (2008) 402.




DOI: https://doi.org/10.2298/JSC171208078T

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