Antimicrobial and anti tubercular activities of isolates and semi synthetic derivatives of lichen Ramalina leiodea (Nyl.) Nyl.

Main Article Content

Vinay Bharadwaj Tatipamula
http://orcid.org/0000-0002-9376-1911
Girija Sastry Vedula
http://orcid.org/0000-0001-6250-8473

Abstract

The chemical investigation of lichen Ramalina leiodea (Nyl.) Nyl. yielded five known metabolites, i.e., usnic acid (1), ethyl everninate (2), scro­biculin (3), methyl 2,6-dihydroxy-4-methylbenzoate (4) and 4-[(2-hydroxy-4-methoxy-6-propylbenzoyl)oxy]-2-methoxy-6-propylbenzoic acid (5). To develop compound libraries on 4, a series of semi-synthetic derivatives was prepared (4ae). All the metabolites and semi-synthetic ana­logues were screened for anti­microbial and anti-tubercular activities. The res­ults showed that compounds 3 and 5 were very active against antibacterial and antifungal strains, while the semi-synthetic analogues 4ae are moderately active on all tested microbial strains. In addition, compounds 4b and 4d showed better antimycobacterial activity with MIC value of 1.6 µg mL-1, than streptomycin with an MIC of 6.25 µg mL-1 against M. tuberculosis. All the semi-synthetic analogues exhibited better anti-tubercular activity than the isolated metabolites. This is the first report on the synthesis and biological activities of these novel benzohydrazide derivatives.

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How to Cite
[1]
V. B. Tatipamula and G. S. Vedula, “) Nyl”., J. Serb. Chem. Soc., vol. 84, no. 6, pp. 555–562, Jul. 2019.
Section
Biochemistry & Biotechnology
Author Biographies

Vinay Bharadwaj Tatipamula, Pharmaceutical Chemistry Department, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, Andhra Pradesh

Research Scholar, Pharmaceutical Chemistry Department

Girija Sastry Vedula, Pharmaceutical Chemistry Department, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, Andhra Pradesh

Professor in Pharmaceutical Chemistry Department

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