PEG mediated synthesis of 6-pyrazinyl- / fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

Shankaraiah Pagilla, Angajala Kishore Kumar, Vianala Sunitha, Anagani Kanaka Durga Bhavani

Abstract


PEG mediated green synthesis of 6-pyrazinyl-/fused pyrazinyl­qu­i­nazolin-4(3H)-ones was developed starting from 6-iodo-3-methyl-2-phenyl­quinazolin-4(3H)-one by means of quinazolinone based internal alkyne/1,2-di­ketone as intermediates using Castro-Stephen coupling reaction / potassium permanganate mediated oxidation and cyclocondensation reactions.


Keywords


KMnO4, Bisazaheterocycle; 1,2-diamine; 1,2-diketone

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DOI: https://doi.org/10.2298/JSC190517014P

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