Synthesis of novel N-substituted benzyl N-(1,3-benzothiazol-2-yl) acetamides and their in vitro antibacterial activities
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Abstract
The novel Schiff bases 3a-3d were synthesized by reacting with 6-methyl-2-aminobenzothiazole and different substituted benzaldehydes. Afterwards, the obtained Schiff bases were reduced with NaBH4 to form amine compounds 4a-4d. In the final step, reaction of the amine with chloroacetyl chloride gave the novel amide derivatives 5a-5d. The structures of the all novel synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, ESI MS, HETCOR, 2D (1H-1H) COSY and elemental analyses. To investigate the antimicrobial activities of the novel synthesized compounds, they were tested against some Gram-positive and Gram-negative bacterial and fungal species and the results were discussed.
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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
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Eskişehir Osmangazi Üniversitesi
Grant numbers 200419032
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