Breaking news: Empirical formulas, molar masses, biosynthesis reactions and thermodynamic properties of virus particles – Biosynthesis and binding of Omicron JN.1 variant of SARS-CoV-2: Scientific paper

Marko Popović; Maja Stevanović; Marija Mihailović

doi:10.2298/JSC240119019P

PDF (2.45 MB) Supplementary Material (2.12 MB)

Published: Apr 1, 2024

Updated: 01.04.2024

DOI: https://doi.org/10.2298/JSC240119019P

Keywords:

biothermodynamics Gibbs energy immune evasion pathogenicity virus time evolution

Marko Popović

University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia

https://orcid.org/0000-0003-0934-5550

Maja Stevanović

Inovation Centre of the Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11120 Beograd, Serbia

https://orcid.org/0000-0002-0383-3935

Marija Mihailović

University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia

https://orcid.org/0000-0003-2451-4818

Abstract

Breaking news are usually disturbing. Natural disasters, wars, epidemics, etc., are reported as breaking news. This paper reports a decreased danger of spreading of epidemics caused by the JN.1 variant, since analyses indicate that infectivity of the new variant is decreased compared to most earlier variants, which is confirmed by the number of cases (7500 daily in USA). Moreover, JN.1, despite the great number of mutations, has not been able to achieve the values of Gibbs energy change of biosynthesis (and thus virus multiplication rate) of the Hu-1 wild type. The research shows that infectivity and pathogenicity of the JN.1 variant has not reached worrying size, which means that there is no reason to expect the epidemiologic situation getting worse.

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[1]

M. Popović, M. Stevanović, and M. Mihailović, “Breaking news: Empirical formulas, molar masses, biosynthesis reactions and thermodynamic properties of virus particles – Biosynthesis and binding of Omicron JN.1 variant of SARS-CoV-2: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 3, pp. 305–320, Apr. 2024.

Issue

Vol. 89 No. 3 (2024)

Section

Biochemistry & Biotechnology

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Funding data

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-47/2023-01/200026

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Breaking news: Empirical formulas, molar masses, biosynthesis reactions and thermodynamic properties of virus particles – Biosynthesis and binding of Omicron JN.1 variant of SARS-CoV-2 Scientific paper