Design, synthesis and antimycobacterial evaluation of some new azaheterocycles with 4,7-phenanthroline skeleton. Part VI

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Cristina Maria Al Matarneh
Catalina Ionica Ciobanu
Ionel I. Mangalagiu
Ramona Danac

Abstract

A feasible study concerning the synthesis, structure and in vitro antimycobacterial evaluation of new 4,7-phenanthroline derivatives is reported. The preparation is straight and efficient, involving an N-alkylation reaction of 4,7-phenanthroline. The structure of the new compounds have been proved by elemental and spectral (IR, 1H and 13C NMR) analysis. The in vitro antimycobacterial evaluation of five synthesized compounds was investigated against Mycobacterium tuberculosis H37Rv under aerobic conditions, two of them being active. A certain influence of substituents from the para position of the benzoyl moiety was observed, the 4,7-phenanthrolin-4-ium salt substituted with (p)chloro-benzoyl showing the most pronounced antimycobacterial activity.

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How to Cite
[1]
C. M. Al Matarneh, C. I. Ciobanu, I. I. Mangalagiu, and R. Danac, “Design, synthesis and antimycobacterial evaluation of some new azaheterocycles with 4,7-phenanthroline skeleton. Part VI”, J. Serb. Chem. Soc., vol. 81, no. 2, pp. 133-140, Nov. 2015.
Section
Organic Chemistry

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