Synthesis and spectral characterization of novel 1,5-benzodiazepine oxime derivatives

Lina Rekovic; Lidija Kosychova; Irina Bratkovskaja; Regina Vidziunaite

doi:10.2298/JSC180226090R

Synthesis and spectral characterization of novel 1,5-benzodiazepine oxime derivatives

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Published: Apr 28, 2019

DOI: https://doi.org/10.2298/JSC180226090R

Keywords:

N-hydroxy UV-Vis extinction coefficient fluorescence quantum yield bathochromic shift

Lina Rekovic

Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Lidija Kosychova

Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Irina Bratkovskaja

Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Regina Vidziunaite

Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Abstract

Three new 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one oximes were synthesized and characterized by the methods of 1H- and 13C-NMR, IR and elemental analysis. Along with previously described compounds bearing one additional methyl group on the 5th nitrogen atom, the new compounds were characterized in bulk by UV–Vis and fluorescence spectroscopy in various solvents. The influence of the nature of the organic solvent on the spectra of the title compounds was investigated and is discussed.

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[1]

L. Rekovic, L. Kosychova, I. Bratkovskaja, and R. Vidziunaite, “Synthesis and spectral characterization of novel 1,5-benzodiazepine oxime derivatives”, J. Serb. Chem. Soc., vol. 84, no. 4, pp. 343–353, Apr. 2019.

Issue

Vol. 84 No. 4 (2019)

Section

Organic Chemistry

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Lina Rekovic, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

PhD student at Department of Bioanalysis, Institute of Biochemistry, Life Sciences Center, Vilnius University, Lithuania

Lidija Kosychova, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Associate professor at Klaipeda University, Faculty of Marine Engineering, Lithuania; researcher at Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania

Irina Bratkovskaja, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Junior research fellow at Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania

Regina Vidziunaite, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Senior research fellow at Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania

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Lina Rekovic, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Lidija Kosychova, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Irina Bratkovskaja, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

Regina Vidziunaite, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius 10223, Lithuania, phone: +370 5 223 4391

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