Computational, antimicrobial, DNA binding and anticancer activities of pyrimidine incorporated ligand and its copper(II) and zinc(II) complexes(II) complexes

Main Article Content

Murugesan Sankarganesh
Nagaraj Revathi
Jeyaraj Dhaveethu Raja
Karunganathan Sakthikumar
Gujuluva Gangatharan Vinoth Kumar
Jegathalaprathaban Rajesh
Manikkam Rajalakshmi
Liviu Mitu

Abstract

In this research article, the synthesis, structural characterization, and biological, DNA binding and anticancer properties of pyrimidine incorporated Schiff base ligand L and its [CuL2](ClO4)2 (1) and [ZnL2](ClO4)2 (2) complexes are reported. The isolated complexes 1 and 2 have significant antibacterial and antifungal properties, greater than those of ligand L. The interaction between protein and L were analyzed by an in silico method. The intercalative binding of the prepared compounds was proved from electronic absorption, fluorometric, cyclic voltammetric and viscometric methods. The calculated binding parameters such as, Kb (2.65×103, L; 7.74×103, 1 and 2.99×103, 2); Ksv (3.30×103, L; 4.31×103, 1 and 3.89×103, 2), and Kapp (2.15×105, L; 3.30×105, 1 and 2.82×105, 2) indicted that complex 1 has better interaction ability than L and complex 2. The in vitro anticancer properties of L, and complexes 1 and 2 against human cancer (MCF-7, HeLa and HEp-2) and normal (NHDF) cell lines were determined by the MTT assay method. The obtained results designated that complexes 1 and 2 exhibited substantial anticancer activity against the cancer cell lines, better than that of L.

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How to Cite
[1]
M. Sankarganesh, “Computational, antimicrobial, DNA binding and anticancer activities of pyrimidine incorporated ligand and its copper(II) and zinc(II) complexes(II) complexes”, J. Serb. Chem. Soc., vol. 84, no. 3, pp. 277–291, Apr. 2019.
Section
Inorganic Chemistry
Author Biographies

Murugesan Sankarganesh, Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram, Tamil Nadu 623 806

Chemistry Research Centre

Nagaraj Revathi, Department of Chemistry, Ramco Institute of Technology, Rajapalayam, Virudhunagar, Tamil Nadu 626 117 and Department of Chemistry, Manonmanium Sundaranar University, Tirunelvi, Tamil Nadu 627 012,

Chemistry

Jeyaraj Dhaveethu Raja, Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram, Tamil Nadu 623 806

Department of Chemistry

Karunganathan Sakthikumar, Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram, Tamil Nadu 623 806

Chemistry Research Centre

Gujuluva Gangatharan Vinoth Kumar, Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram, Tamil Nadu 623 806

Chemistry Research Centre

Jegathalaprathaban Rajesh, Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram, Tamil Nadu 623 806

Chemistry Research Centre

Manikkam Rajalakshmi, Bioinformatics Centre, PG & Research Centre Department of Biotechnology and Bioinformatics, Holy Cross College (Autonomous), Tiruchirapalli, Tamil Nadu 620 002

Bioinformatics

Liviu Mitu, Department of Nature Sciences, University of Pitesti, Pitesti 110 040

Natural Sciences

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