Hybrid mesoporous silica with controlled drug release

Laszlo Almasy, Ana-Maria Putz, Qiang Tian, Gennady P. Kopitsa, Tamara V. Khamova, Reka Barabas, Melinda Rigo, Attila Bota, Andras Wacha, Marius C. Mirica, Bogdan O. Taranu, Cecilia Savii

Abstract


The mesoporous silica particles were prepared by the sol–gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyl­triethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammoni­um bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated pre­cursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.


Keywords


sol–gel process; ketoprofen; hybrid material; SAXS

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DOI: https://doi.org/10.2298/JSC181109009A

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