Folic acid conjugation of magnetite nanoparticles using pulsed electrohydraulic discharges

Vladimer Mikelashvili, Shalva Kekutia, Jano Markhulia, Liana Saneblidze, Zaur Jabua, László Almásy, Manfred Kriechbaum

Abstract


The sonochemical coprecipitation reaction with moderate ultrasound irradiation in low vacuum environment was used to obtain aqueous colloidal suspensions of iron oxide nanoparticles (IONPs). Synthesized magnetite nanoparticles were conjugated directly by Folic Acid using electrohydraulic discharges as a processing technique before modification of the surface of the nanoparticles. Electrohydraulic discharges were applied in two operational modes with high and low power pulsed direct currents between the electrodes. The physical and chemical properties of the obtained samples were studied using X-Ray Powder Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), and Small Angle X-Ray Scattering (SAXS). The investigation has proved an inverse cubic spinel structure of magnetite with Folic Acid attachment to the magnetite surface (mean crystallite diameter in the samples D = 27~29 ± 2 nm by XRD and SAXS). It was found that the processing with electrohydraulic discharges increases the colloidal stability of the Folic acid-magnetite nanoparticle dispersions.

Keywords


iron oxide nanoparticles; sonochemical coprecipitation; pulsed arc discharge; surface functionalization

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References


L. A. Yutkin, Electro-hydraulic effect and its application in industry, Engineering, Leningrad, Russia, 1986, p. 252 (in Russian) (http://bourabai.ru/library/elektrogidravlicheski_effekt.pdf)

E. Leal-Quirós, Brazilian J. Phys. 34 (2004) 1587 (http://dx.doi.org/10.1590/S0103-97332004000800015)

G. Saito, T. Akiyama, J. Nanomater. 2015 (2015) 1 (http://dx.doi.org/10.1155/2015/123696)

H. Li, K. Wang, X. Tuo, L. Almásy, Q. Tian, G. Sun, M. J. Henderson, Q. Li, A. Wacha, J. Courtois, M. Yan, Mater. Chem. Phys. 204 (2018) 236 (http://dx.doi.org/10.1016/j.matchemphys.2017.10.047)

S. Horikoshi, N. Serpone, RSC Adv. 7 (2017) 47196 (http://dx.doi.org/10.1039/c7ra09600c)

Ruma, H. Hosano, T. Sakugawa, H. Akiyama, Catalysts 8 (2018) 213 (http://dx.doi.org/10.3390/catal8050213)

S. Wakisaka, K. Tsuda, K. Takahashi, K. Satoh, IEEE Trans. Plasma Sci. 47 (2019) 1083 (https://doi.org/10.1109/TPS.2018.2866282)

H. Shiraishi, G. R. Sunaryo, K. Ishigure, J. Phys. Chem. 98 (1994) 5164 (https://doi.org/10.1021/j100070a037)

M. I. Lerner, I. A. Gorbikov, O. V. Bakina, S. O. Kasantzev, Inorg. Mater. Appl. Res. 8 (2017) 473 (http://dx.doi.org/10.1134/S2075113317030169)

P. M. Price, W. E. Mahmoud, A. A. Al-Ghamdi, L. M. Bronstein, Front. Chem. 6 (2018) 619 (http://dx.doi.org/10.3389/fchem.2018.00619)

T. Vangijzegem, D. Stanicki, S. Laurent, Expert Opin. Drug Deliv. 16 (2019) 69 (http://dx.doi.org/10.1080/17425247.2019.1554647)

S. Palanisamy, Y. M. Wang, Dalton Trans. 48 (2019) 9391 (http://dx.doi.org/10.1039/c9dt00459a)

A. Stepanov, R. Mendes, M. Rümmeli, T. Gemming, I. Nizameev, A. Mustafina, Chem. Pap. 73 (2019) 2715 (http://dx.doi.org/10.1007/s11696-019-00823-9)

A. Ali, H. Zafar, M. Zia, I. ul Haq, A. R. Phull, J. S. Ali, A. Hussain, Nanotechnol. Sci. Appl. 9 (2016) 49 (http://dx.doi.org/10.2147/NSA.S99986)

H. Arami, Z. Stephen, O. Veiseh, M. Zhang, Adv. Polym. Sci. 243 (2011) 163 (http://dx.doi.org/10.1007/12_2011_121)

T. Keskin, S. Yalcin, U. Gunduz, Inorg. Nano-Metal Chem. 48 (2018) 150 (http://dx.doi.org/10.1080/24701556.2018.1453840)

M. Erdem, S. Yalcin, U. Gunduz, Hum. Exp. Toxicol. 36 (2017) 833 (http://dx.doi.org/10.1177/0960327116672910)

H. Yoo, S. K. Moon, T. Hwang, Y. S. Kim, J. H. Kim, S. W. Choi, J. H. Kim, Langmuir 29 (2013) 5962 (http://dx.doi.org/10.1021/la3051302)

A. Ancira-Cortez, E. Morales-Avila, B. E. Ocampo-Garciá, C. González-Romero, L. A. Medina, G. López-Téllez, E. Cuevas-Yáñez, J. Nanomater. 2017 (2017) 1 (http://dx.doi.org/10.1155/2017/5184167)

Q. L. Jiang, S. W. Zheng, R. Y. Hong, S. M. Deng, L. Guo, R. L. Hu, B. Gao, M. Huang, L. F. Cheng, G. H. Liu, Y. Q. Wang, Appl. Surf. Sci. 307 (2014) 224 (http://dx.doi.org/10.1016/j.apsusc.2014.04.018)

J. Chen, S. Klem, A. K. Jones, B. Orr, M. M. B. Holl, Bioconjug. Chem. 28 (2017) 81 (http://dx.doi.org/10.1021/acs.bioconjchem.6b00526)

J. Markhulia, V. Mikelashvili, S. Kekutia, L. Saneblidze, Z. Jabua, D. Daraselia, D. Jafaridze, J. Pharm. Appl. Chem. 2 (2016) 33 (http://dx.doi.org/10.18576/jpac/020201)

J. Markhulia, S. Kekutia, Z. Jabua, V. Mikelashvili, L. Saneblidze, Chemical co-precipitation synthesis and characterization of polyethylene glycol coated iron oxide nanoparticles for biomedical applications, 7th International Multidisciplinary Scientific GeoConference SGEM 2017, (2017), Sofia, Bulgaria, SGEM2017 Conference Proceedings 17, SGEM, Sofia, 2017, 51-58 (http://dx.doi.org/10.5593/sgem2017/61/S24.007)

J. Markhulia, S. Kekutia, N. Mitskevich, V. Mikelashvili, L. Saneblidze, N. Leladze, Z. Jabua, L. Sacarescu, M. Kriechbaum, L. Almásy, Dig. J. Nanomater. Biostructures 13 (2018) 1081 (http://www.chalcogen.ro/1081_MarkhuliaJ.pdf)

A. F. C. Campos, W. C. De Medeiros, R. Aquino, J. Depeyrot, Mater. Res. 20 (2017) 1729 (http://dx.doi.org/10.1590/1980-5373-MR-2017-0649)

E. Illés, E. Tombácz, J. Colloid Interface Sci. 295 (2006) 115 (https://doi.org/10.1016/j.jcis.2005.08.003)

F. Márquez, G. M. Herrera, T. Campo, M. Cotto, J. Ducongé, J. M. Sanz, E. Elizalde, Ó. Perales, C. Morant, Nanoscale Res. Lett. 7 (2012) 210 (http://dx.doi.org/10.1186/1556-276X-7-210)

M. Mahdavi, M. Bin Ahmad, M. J. Haron, F. Namvar, B. Nadi, M. Z. Ab Rahman, J. Amin, Molecules 18 (2013) 7533 (http://dx.doi.org/10.3390/molecules18077533)

D. Franke, M. V. Petoukhov, P. V. Konarev, A. Panjkovich, A. Tuukkanen, H. D. T. Mertens, A. G. Kikhney, N. R. Hajizadeh, J. M. Franklin, C. M. Jeffries, D. I. Svergun, J. Appl. Crystallogr. 50 (2017) 1212 (http://dx.doi.org/10.1107/S1600576717007786)

P. V. Konarev, V. V. Volkov, A. V. Sokolova, M. H. J. Koch, D. I. Svergun, J. Appl. Crystallogr. 36 (2003) 1277 (http://dx.doi.org/10.1107/S0021889803012779)

A. Guinier, G. Fournet. Small-Angle Scattering of X-rays, Wiley, New York, USA, 1955 (https://pdfs.semanticscholar.org/e307/79ad3cf2fb2e2c0a4d6c6b9f6a92bafec4a8.pdf)

A. V. Semenyuk, D. I. Svergun, J. Appl. Crystallogr. 24 (1991) 537 (http://dx.doi.org/10.1107/S002188989100081X)

D. I. Svergun, J. Appl. Crystallogr. 24 (1992) 495 (http://dx.doi.org/10.1107/S0021889892001663)

D. Franke, D. I. Svergun, J. Appl. Crystallogr. 42 (2009) 342 (http://dx.doi.org/10.1107/S0021889809000338)

S. Zhu, Y. Leng, M. Yan, X. Tuo, J. Yang, L. Almásy, Q. Tian, G. Sun, L. Zou, Q. Li, J. Courtois, H. Zhang, Appl. Surf. Sci. 447 (2018) 381 (http://dx.doi.org/10.1016/j.apsusc.2018.04.016)

D. F. Coral-Coral, J. A. Mera-Córdoba, DYNA 86 (2019) 135 (http://dx.doi.org/10.15446/dyna.v86n209.73450)

V. I. Petrenko, O. P. Artykulnyi, L. A. Bulavin, L. Almásy, V. M. Garamus, O. I. Ivankov, N. A. Grigoryeva, L. Vekas, P. Kopcansky, M. V. Avdeev, Colloids Surf., A 541 (2018) 222 (http://dx.doi.org/10.1016/j.colsurfa.2017.03.054)

A. Taufiq, Sunaryono, N. Hidayat, A. Hidayat, E. G. R. Putra, A. Okazawa, I. Watanabe, N. Kojima, S. Pratapa, Darminto, Nano 12 (2017) 1750110 (http://dx.doi.org/10.1142/S1793292017501107)

B. R. Pauw, J. S. Pedersen, S. Tardif, M. Takata, B. B. Iversen, J. Appl. Crystallogr. 46 (2013) 365 (http://dx.doi.org/10.1107/S0021889813001295)

B. R. Pauw, C. Kästner, A. F. Thünemann, J. Appl. Crystallogr. 50 (2017) 1280 (http://dx.doi.org/10.1107/S160057671701010X)




DOI: https://doi.org/10.2298/JSC200414053M

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