Phytochemical investigation of Pimpinella serbica Scientific paper

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Ivan Vučković
Sonja Stiković
Danijela Stešević
Milka Jadranin
Snežana Trifunović


The plant species Pimpinella serbica (Vis.) Drude, endemic to West Balkans, belongs to the genus Pimpinella L. (Apiaceae) according to newer botanical classification. Initially, the plant was described as Pancicia serbica Vis. and long considered as a monotypic genus. Previous phytochemical inves­tigations of this plant were limited to the essential oil analysis by the GC–MS method. This is first study that includes LC-DAD–MS screening of the extracts of the roots and aerial parts, followed by isolation of secondary metabolites using chromatographic techniques. Five compounds belonging to phenylpropanoids and polyacetylenes, well known for their bioactivities, were isolated and struc­turally determined by combined spectroscopic methods (UV, NMR, MS). Dil­lapiole (1), nothoapiole (2) and oplopantriol A 18-acetate (4) were found in both extracts, while falcarindiol (3) was isolated from the roots and dendrotrifidol (5) from the aerial parts only. The phytochemical profile of P. serbica L. supports its position in the Pimpinella L. genus.


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I. Vučković, S. Stiković, D. Stešević, M. Jadranin, and S. Trifunović, “Phytochemical investigation of Pimpinella serbica: Scientific paper”, J. Serb. Chem. Soc., vol. 86, no. 12, pp. 1241–1247, Dec. 2021.
Theme issue honoring Professor Emeritus Slobodan Milosavljevićs 80th birthday


Apiaceae, in A Dictionary of Plant Sciences (4th ed.), M. Allaby Ed., Oxford University Press, New York, 2019 (

M. G. Pimenov, M. V. Leonov, The Genera of the Umbelliferae, Royal Botanic Gardens, Kew, 1993, p. 156 (ISBN 0-947643-58-3)

Assessment report on Pimpinella anisum L., Doc. Ref: EMEA/HMPC/137421/2006 (, accessed August 2021)

Euro+Med PlantBase - the information resource for Euro-Mediterranean plant diversity (, accessed August 2021)

V. Nikolić in Flora SR Srbije V, M. Josifović, Ed., SASA, Belgrade, 1975, p. 229 (in Serbian)

T. G. Tutin, Genus Pimpinella, in Flora Europaea, Vol 2, T. G. Tutin, V. H. Heywood, N. A. Burges, D. M. Moore, D. H. Valentine, S. M. Walters, D. A. Webb, Eds., Cambridge University Press, Cambridge, 1968, p. 332 (ISBN 9780521066624)

R. Ivanic, K. Savin, F. V. Robinson, Planta Med. 48 (1983) 60 (

C. Kapetanos, A. Kariot, S. Bojovic, P. Marin, M. Velic, H. Skaltsa, Chem. Biodivers. 5 (2008) 101 (

I. Vučković, L. Vujisić, M. Todosijević, D. Stešević, S. Milosavljević, S. Trifunović, Rec. Nat. Prod. 8 (2014) 148 (

A. R. S. Chauhan, M.C. Nautiyal, R. Cecotti, M. Mella, A. Tava, Ind. Crops Product. 94 (2016) 401 (

L. P. Christensen, K. Brandt, J. Pharm. Biomed. Anal. 41 (2006) 683 (

C. Seger, M. Godejohann, M. Spraul, H. Stuppner, F. Hadacek, J. Chromatogr., A 1136 (2006) 82 (

I. Vucković, V. Vajs, M. Stanković, V. Tesević, S. Milosavljević, Chem. Biodivers. 7 (2010) 698 (

E. Lemmich, Phytochemistry 20 (1981) 1419 (

M. Kobaisy, Z. Abramowski, L. Lermer, G. Saxena, R. E. Hancock, G. H. Towers, D. Doxsee, R. W. Stokes, J. Nat. Prod. 60 (1997) 1210 (

A. Kobayashi, K. Tamagawa, K. Yamashita, Agric. Biol. Chem. 41 (1977) 691 (

N. Tabanca, G. Ma, D. S. Pasco, E. Bedir, N. Kirimer, K. H. Can Baser, I. A. Khan, S. I. Khan, Phytother. Res. 21 (2007) 741 (

R. Parise-Filho, M. Pastrello, C. E. Pereira Camerlingo, G. J. Silva, L. A. Agostinho, T. de Souza, F. M. Motter Magri, R. R. Ribeiro, C. A. Brandt, M. C. Polli, Pharm. Biol. 49 (2011) 1173 (

R. Rojas-Martínez, J. Arrieta, L. Cruz-Antonio, D. Arrieta-Baez, A. M. Velázquez-Méndez, M. E. Sánchez-Mendoza, Molecules 18 (2013) 11327 (

H. Laouer, E. K. Meriem, S. Prado, N. Baldovini, Phytother. Res. 23 (2009) 1726 (

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