Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes

Jelena Lović, Jelena Lađarević, Dušan Mijin, Milka Jadranin, Slobodan Petrović, Milka Avramov Ivić

Abstract


In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta­mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec­trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me­thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.


Keywords


cyclic voltammetry; square wave voltammetry; Au electrode; GC electrode; IrOX electrode; total organic carbon analysis

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DOI: https://doi.org/10.2298/JSC190731091L

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