Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes

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Jelena Lović
Jelena Lađarević
Dušan Mijin
Milka Jadranin
Slobodan Petrović
Milka Avramov Ivić


In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave volta­mmetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corres­ponding N-carbonyl guanidine via oxime intermediate is suggested. The sta­bi­lity of MET was tested under directed stress conditions using IrOx elec­trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me­thyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical pro­cesses at three electrodes were followed by UV spectro­scopy and evaluated by total organic carbon analysis.

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How to Cite
J. Lović, J. Lađarević, D. Mijin, M. Jadranin, S. Petrović, and M. Avramov Ivić, “Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes”, J. Serb. Chem. Soc., vol. 84, no. 11, pp. 1319-1327, Dec. 2019.
In Memoriam Issue Devoted to Prof. Konstantin Popov


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