The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines Scientific paper

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Published: Mar 4, 2024
Updated: 04.03.2024
DOI: https://doi.org/10.2298/JSC231023098N
Keywords:
biologically active compounds DPPH analysis ABTS analysis broth microdilution method

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Jasmina Nikolić
Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade
https://orcid.org/0000-0003-1202-968X
Nevena Prlainović
Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
Gavrilo Šekularac
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
https://orcid.org/0000-0002-6370-4983
Luka Matović
Innovations Center of Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
https://orcid.org/0000-0003-4945-7776
Saša Drmanić
Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
https://orcid.org/0000-0002-9985-0819
Anita Lazić
Innovations Center of Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
https://orcid.org/0000-0003-4855-3782

Abstract

The esters of substituted 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of an appropriate aldehyde and ethyl acetoacetate in the pre­sence of concentrated water solution of ammonia. The esters form the amides by the reaction with primary amines. The series of the amides has been syn­thesized with the aim to analyze their chemical characteristics, antioxidant and antimicrobial activity. The amine used in this research is 2-aminothiazole. The antioxidant activity is analysed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) methods and the antimicrobial activity screening was performed by broth microdilution method, using different microbial strains. The characterization of the obtained amides was done by melting points, FTIR, NMR and elemental analysis. The possibil­ities for further research was suggested, which could lead to the application of selected compounds.

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How to Cite
[1]
J. Nikolić, N. Prlainović, G. Šekularac, L. Matović, S. Drmanić, and A. Lazić, “The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 2, pp. 141–150, Mar. 2024.
Issue
Vol. 89 No. 2 (2024)
Section
Organic Chemistry
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Author Biography

Jasmina Nikolić, Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade

Assistant Professor

Faculty of Technology and Metallurgy

University of Belgrade

 

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