Microwave assisted synthesis of 2-(2-(Tetrazolo[1,5-a]quinolin-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl) substituted phenols and evaluation of their antimicrobial activity

Dongamanti Ashok, Velagapuri Hanumantha Rao, Rangu Kavitha


A series of new benzodiazepines 4a-h have been synthesized by Michael addition of chalcones 3a-h with o-phenylenediamine (OPDA) in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized benzodiazepines 4a-h have been established on the basis of IR, 1H & 13C NMR and mass spectral data and tested for antimicrobial activity.


Antimicrobial activity; benzodiazepines; chalcones; Michael addition; microwave irradiation; tetrazolo quinoline aldehyde.

DOI: https://doi.org/10.2298/10.2298/JSC150504041A

Copyright (c) 2016 Journal of the Serbian Chemical Society - J. Serb. Chem. Soc.

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