Microwave assisted synthesis of 1H-tetrazole based flavonoid derivatives and their antimicrobial activity

Dongamanti Ashok, Nalaparaju Nagaraju, Madderla Sarasija, B Vijaya Lakshmi

Abstract


A series of novel tetrazole scaffolds containing chalcones 4a-e and aurones 5a-e have been synthesized under conventional and microwave irradiation methods. All the newly synthesized compounds were characterized by IR, NMR and Mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli as well as fungi such as Aspergillus Niger, Aspergillus flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all pathogenic bacteria and fungi.


Keywords


4-(1H-tetrazol-5-yl) benzaldehyde; chalcone; aurone; microwave irradiation; antimicrobial activity

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DOI: https://doi.org/10.2298/10.2298/JSC170825064A

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