Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′-yl]-2H-chromen-5-ols

Dongamanti Ashok, Rangu Kavitha, Srinivas Gundu, Madderla Sarasija

Abstract


A new series of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′-
-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chal­cones 5aj with hydrazine hydrate in presence of sodium acetate under con­ventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6aj were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6cf and 6i showed promising antimicrobial potency.


Keywords


pyrazole; pyrazoline; microwave irradiation; antimicrobial activity

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