Microwave-assisted synthesis and antimicrobial evaluation of 6-(3'-(aryl)-1'-phenyl-3,4-dihydro-1'H,2H-[3,4'-bipyra-zol]-5-yl)-2H-chromen-5-ols

Dongamanti Ashok, Rangu Kavitha, Srinivas Gundu, Madderla Sarasija

Abstract


A new series of 6-(3'-(aryl)-1'-phenyl-3,4-dihydro-1'H,2H-[3,4'-bipyra­zol]-5-yl)-2H-chromen-5-ol derivatives has been synthesized by Michael addition of chalcones (5a–j) with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the products was confirmed on the basis of IR, 1H NMR, 13C NMR, MS and analytical data. All the synthesized compounds (6a-j) were screened for antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c, 6d, 6e, 6f and 6i showed promising antimicrobial potency.


Keywords


pyrazole; pyrazoline; microwave irradiation; antimicrobial activity

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