Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine: A green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/tiones derivatives under solvent-free conditions

Farzaneh Mohamadpour, Mojtaba Lashkari

Abstract


Caffeine is found to be a natural and green and biodegradable catalyst for one-pot, three-component condensation Biginelli reaction of β-keto esters, aromatic aldehydes and urea/ thiourea to afford the corresponding 3, 4-dihydropyrimidin-2-(1H)-ones/tiones derivatives under solvent-free conditions. The remarkable features of this green procedure are high yields, short reaction times, simplicity of operation and work-up procedures, the availability and easy to handle of this solid catalyst, avoidance of hazardous or toxic catalysts and organic solvents and economic availability of the catalyst.

Keywords


caffeine; natural and green biodegradable catalyst; Biginelli reaction; 3,4-dihydropyrimidin-2-(1H)-ones/tiones derivatives; eco-safe procedure; solvent-free conditions

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DOI: https://doi.org/10.2298/JSC170712041M

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