Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles

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Farzaneh Mohamadpour


A highly versatile and convenient synthetic route for biologically act­ive α-amino acid, glutamic acid catalyzed facile and mild preparation of poly­functionalized dihydro-2-oxypyrroles via one-pot, four condensation dom­ino reaction between aromatic/aliphatic amines, dialkyl acetylenedicar­boxyl­ates and formaldehyde have been studied. The route includes green, biodegradable and inexp­ensive α-amino acid catalyst, high atom-economy, simplicity of oper­at­ion and work-up procedures, without chromatographic purification steps. The solid cat­alyst, non-toxic or hazardous, easily handled with mild reaction con­ditions and excellent yields are the notable benefits of the highly efficient and expedient synthesis of these products.


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F. Mohamadpour, “Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles”, J. Serb. Chem. Soc., vol. 84, no. 10, pp. 1083–1092, Nov. 2019.
Organic Chemistry


A. D. Borthwick, A. J. Crame, P. F. Ertl, A. M. Exall, T. M. Haley, G. J. Hart, A. M. Mason, M. K. Pennell, O. M. P. Singh, G. G. Weingarten, J. M. Woolven, J. Med. Chem. 45 (2002) 1 (

C. Alp, D. Ekinci, M. S. Gultekin, M. Senturk, E. Sahin, O. Kufrevioglu, Bioorg. Med. Chem. 18 (2010) 4468 (

R. Shiraki, A. Sumino, K. Tadano, S. Ogawa, Tetrahedron Lett. 36 (1995) 5551 (

Y. L. Lampe, R. G. Chou, R. G. Hanna, S. V. DiMeo, P. W. Erhardt, A. A. Hagedorn, W. R. Ingebretsen, E. Cantor, J. Med. Chem. 36 (1993) 1041 (10.1021/jm00060a012)

Y. Chen, D. X. Zeng, N. Xie, Y. Z. Dang, J. Org. Chem. 70 (2005) 5001 (10.1021/jo050236r)

S. B. Singh, M. A. Goetz, E. T. Jones, G. F. Billes, R. A. Giacobbe, L. Herranz, S. Stevens Miles, D. L. Williams, J. Org. Chem. 60 (1995) 7040 (10.1021/jo00126a071)

C. Peifer, R. Selig, K. Kinkel, D. Ott, F. Totzke, C. Scha¨chtele, R. Heidenreich, M. Ro¨cken, D. Schollmeyer, S. Laufer, J. Med. Chem. 51 (2008) 3814 (10.1021/jm8001185)

8. A. T. Khan, A. Ghosh, M. Musawwer Khan, Tetrahedron Lett. 53 (2012) 2622 (

S. S. Sajadikhah, M. T. Maghsoodlou, N. Hazeri, J. Chin. Chem. Lett. 25 (2014) 58 (

S. S. Sajadikhah, N. Hazeri, J. Res. Chem. Intermed. 40 (2014) 737 (

S. S. Sajadikhah, N. Hazeri, M. T, Maghsoodlou, S. M. HabibiKhorasani, A. Beigbabaei, A. C. Willis., J. Iran. Chem. Soc. 10 (2013) 863 (

Q. Zhu, H. Jiang, J. Li, S. Liu, C. Xia, M. Zhang, J. Comb. Chem. 11 (2009) 685 (

L. Lv, S. Zheng, X. Cai, Z. Chen, Q. Zhu, S. Liu, J. Acs. Comb. Sci. 15 (2013) 183 (

S. S. Sajadikhah, N. Hazeri, M. T. Maghsoodlou, J. Chem. Res. 37 (2013) 40 (

S. S. Sajadikhah, M. T. Maghsoodlou, N. Hazeri, S. Mohamadian-Souri, Res. Chem. Intermed. 42 (2016) 2805 (

16. Md. M. Khan, S. Khan, S. Iqbal, Saigal, R. Yousuf, New J. Chem. 40 (2016) 7504 (

N. Salehi, B. B. F. Mirjalili, RSC Adv. 7 (2017) 30303 (10.1039/C7RA04101B)

M. Zarei, S. S. Sajadikhah, Res. Chem. Intermed. 42 (2016) 7005 (

F. Mohamadpour, M. Lashkari, J. Serb. Chem. Soc. 83 (2018) 673 (

M. R. Simić, M. R. Petković, P. M. Jovanović, G. D. Tasić, V. M. Savić, J. Serb. Chem. Soc. 82 (2017) 1335 (

F. Saadati, V. Leghaei, A. Zamani, J. Serb. Chem. Soc. 82 (2017) 1211 (

G. K Padhy, J. Panda, A. K. Behera, J. Serb. Chem. Soc. 82 (2017) 985 (

F. Mohamadpour, M. T. Maghsoodlou, R. Heydari, M. Lashkari, Res. Chem. Intermed. 42 (2016) 7841 (

F. Mohamadpour, Polycycl. Aromat. Compd. (2018) (