Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles
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Abstract
A highly versatile and convenient synthetic route for biologically active α-amino acid, glutamic acid catalyzed facile and mild preparation of polyfunctionalized dihydro-2-oxypyrroles via one-pot, four condensation domino reaction between aromatic/aliphatic amines, dialkyl acetylenedicarboxylates and formaldehyde have been studied. The route includes green, biodegradable and inexpensive α-amino acid catalyst, high atom-economy, simplicity of operation and work-up procedures, without chromatographic purification steps. The solid catalyst, non-toxic or hazardous, easily handled with mild reaction conditions and excellent yields are the notable benefits of the highly efficient and expedient synthesis of these products.
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