In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-(naphthoquinone)cysteine derivatives

Nebojša Pantelić, Martina Lerbs, Katharina Wolf, Ludger Wessjohann, Goran N Kaluđerović

Abstract


Triphenyltin(IV) compounds with naphthoquinone derivatives conta­ining N-acetylcysteine, N-acetyl-S-(1,2-dion-4-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dion-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (1H, 13C, 119Sn) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel syn­the­sized organotin(IV) compounds against human cervix adeno­car­ci­noma (HeLa), human colon carcinoma (HT-29), and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indi­cate that syn­the­sized compounds exhibited remarkable antiproliferative activity to­ward all tested cell lines with IC50 in the range of 0.17 to 0.87 µM. Complex 1 showed the greatest activity against HT-29 cells, with IC50 value of 0.21 ± 0.01 µM, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC50 = 0.17 ± 0.01 µM, which is ~26 times better than cisplatin.

Keywords


organotin(IV) compounds; characterization; antitumor agents; cytotoxicity

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DOI: https://doi.org/10.2298/JSC190322032P

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