In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives

Nebojša Pantelić; Martina Lerbs; Katharina Wolf; Ludger Wessjohann; Goran N. Kaluđerović

doi:10.2298/JSC190322032P

PDF (2,251 kB) Supplementary Material (1.88 MB)

Published: Nov 10, 2019

DOI: https://doi.org/10.2298/JSC190322032P

Keywords:

organotin(IV) compounds characterization antitumor agents cytotoxicity

Nebojša Pantelić

Department of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, Nemanjina 6, Belgrade-Zemun

Martina Lerbs

Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle (Saale)

Katharina Wolf

Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle (Saale)

Ludger Wessjohann

Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle (Saale)

Goran N. Kaluđerović

Department of Engineering and Natural Sciences University of Applied Sciences Merseburg Eberhard-Leibnitz-Strasse 2, 06217 Merseburg

https://orcid.org/0000-0001-5168-1000

Abstract

Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(3,4-dihydro-3,4-dioxo-1-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dihydro-1,4-dioxo-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized and characterized by elemental microanalysis, IR, multinuclear (¹H, ¹³C, ¹¹⁹Sn) NMR spectroscopy as well as HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination of ligand precursors and novel synthesized organotin(IV) compounds against human cervix adenocarcinoma (HeLa), human colon carcinoma (HT-29) and melanoma carcinoma cell line (B16F10), MTT colorimetric assay method was applied. The results indicate that synthesized compounds exhibited remarkable antiproliferative activity toward all tested cell lines with IC₅₀ in the range from 0.17 to 0.87 µM. Complex 1 showed the greatest activity against HT-29 cells, with IC₅₀ value of 0.21±0.01 µM, 119 times better than cisplatin, while complex 2 demonstrated the highest activity toward HeLa cells, IC₅₀ = 0.17±0.01 µM, which is ~26 times better than cisplatin.

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N. Pantelić, M. Lerbs, K. Wolf, L. Wessjohann, and G. N. Kaluđerović, “In vitro anticancer evaluation of novel triphenyltin(IV) compounds with some N-acetyl-S-naphthoquinonylcysteine derivatives”, J. Serb. Chem. Soc., vol. 84, no. 10, pp. 1119–1127, Nov. 2019.

Issue

Vol. 84 No. 10 (2019)

Section

Inorganic Chemistry

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

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