Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones Scientific paper

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Božidar Čobeljić
http://orcid.org/0000-0001-6335-0196
Marijana Živković
Ivana Matić
https://orcid.org/0000-0001-7364-2619
Irena Novaković
Dušan Sladić
http://orcid.org/0000-0002-1000-9813
Katarina Anđelkovic
http://orcid.org/0000-0003-1178-8326
Natalija Krstić
https://orcid.org/0000-0002-2356-6803

Abstract

In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.

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How to Cite
[1]
B. Čobeljić, “Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones: Scientific paper”, J. Serb. Chem. Soc., vol. 86, no. 5, pp. 459–468, Jun. 2021.
Section
Inorganic Chemistry

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