Structure and DNA/BSA binding study of zinc(II) complex with 4-ethynyl-2,2’-bipyridine: Scientific paper

Tina  Andrejević; Darko  Ašanin; Aurélien  Crochet; Nevena  Stevanović; Ivana  Vučenović; Fabio  Zobi; Miloš  Djuran; Biljana Glišić

doi:10.2298/JSC230605066A

PDF (1.48 MB) Supplementary Material (1.11 MB)

Published: Dec 25, 2023

Updated: 25.12.2023

DOI: https://doi.org/10.2298/JSC230605066A

Keywords:

zinc(II) bipyridine structural characterization protein interactions DNA interactions

Tina Andrejević

University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia

https://orcid.org/0000-0002-9537-5926

Darko Ašanin

University of Kragujevac, Institute for Information Technologies Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia

https://orcid.org/0000-0003-1098-400X

Aurélien Crochet

University of Fribourg, Department of Chemistry, Chemin du Musée 9, CH-1700 Fribourg, Switzerland

https://orcid.org/0000-0002-4763-2764

Nevena Stevanović

University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia

https://orcid.org/0000-0003-3261-478X

Ivana Vučenović

University of Niš, Faculty of Agriculture Kruševac, Kosančićeva 4, 37000 Kruševac, Serbia

https://orcid.org/0000-0003-3927-7915

Fabio Zobi

University of Fribourg, Department of Chemistry, Chemin du Musée 9, CH-1700 Fribourg, Switzerland

https://orcid.org/0000-0002-9077-7184

Miloš Djuran

Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia

https://orcid.org/0000-0003-2763-2852

Biljana Glišić

University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia

https://orcid.org/0000-0002-6343-8611

Abstract

In the present study, a zinc(II) complex with 4-ethynyl-2,2’-bipyridine (ebpy), [Zn(ebpy)Cl₂], was synthesized and characterized by spectroscopic (¹H-NMR, IR and UV–Vis) methods and molar conductivity measurement. The crystal structure of the [Zn(ebpy)Cl₂] complex was determined by single-crystal X-ray diffraction analysis, confirming the bidentate coordination of the ebpy ligand through its two nitrogen atoms, while the remaining two coordination sites are occupied by two chloride ions. With the aim to investigate the reactivity of the synthesized zinc(II) complex toward biologically important molecules, its binding affinity to calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied by fluorescence emission spectroscopy. From the obtained results, it can be concluded that [Zn(ebpy)Cl₂] complex binds to bovine serum albumin reversibly, while the combination of ethidium bromide (EthBr) and Hoechst 33258 (2’-(4-hydroxyphenyl)-5-[5-(4-methylpiperazine-1-yl)benzimidazo-2-yl]-benzimidazole) competitive binding study suggests that this complex interacts with ct-DNA through the minor groove binding, which is in agreement with molecular docking study.

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How to Cite

[1]

T. . Andrejević, “Structure and DNA/BSA binding study of zinc(II) complex with 4-ethynyl-2,2’-bipyridine: Scientific paper”, J. Serb. Chem. Soc., vol. 88, no. 12, pp. 1293–1306 , Dec. 2023.

Issue

Vol. 88 No. 12 (2023): Theme issue honoring Professor Vukadin Leovac's 80th birthday

Section

Theme issue honoring Professor Vukadin Leovac's 80th birthday

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Funding data

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-451-03-47/2023-01/200122;451-03-47/2023-01/200378
Serbian Academy of Sciences and Arts
Grant numbers F128

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Structure and DNA/BSA binding study of zinc(II) complex with 4-ethynyl-2,2’-bipyridine Scientific paper