The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines: Scientific paper

Jasmina Nikolić; Nevena Prlainović; Gavrilo Šekularac; Luka Matović; Saša Drmanić; Anita Lazić

doi:10.2298/JSC231023098N

PDF (1.20 MB) Supplementary Material (5.98 MB)

Published: Mar 4, 2024

Updated: 04.03.2024

DOI: https://doi.org/10.2298/JSC231023098N

Keywords:

biologically active compounds DPPH analysis ABTS analysis broth microdilution method

Jasmina Nikolić

Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade

https://orcid.org/0000-0003-1202-968X

Nevena Prlainović

Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

Gavrilo Šekularac

Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0002-6370-4983

Luka Matović

Innovations Center of Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0003-4945-7776

Saša Drmanić

Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0002-9985-0819

Anita Lazić

Innovations Center of Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

https://orcid.org/0000-0003-4855-3782

Abstract

The esters of substituted 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of an appropriate aldehyde and ethyl acetoacetate in the presence of concentrated water solution of ammonia. The esters form the amides by the reaction with primary amines. The series of the amides has been synthesized with the aim to analyze their chemical characteristics, antioxidant and antimicrobial activity. The amine used in this research is 2-aminothiazole. The antioxidant activity is analysed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) methods and the antimicrobial activity screening was performed by broth microdilution method, using different microbial strains. The characterization of the obtained amides was done by melting points, FTIR, NMR and elemental analysis. The possibilities for further research was suggested, which could lead to the application of selected compounds.

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How to Cite

[1]

J. Nikolić, N. Prlainović, G. Šekularac, L. Matović, S. Drmanić, and A. Lazić, “The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 2, pp. 141–150, Mar. 2024.

Issue

Vol. 89 No. 2 (2024)

Section

Organic Chemistry

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Jasmina Nikolić, Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade

Assistant Professor

Faculty of Technology and Metallurgy

University of Belgrade

Funding data

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-47/2023-01/200135

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The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines Scientific paper